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Literature summary extracted from

  • Xu, Y.L.; Lin, H.Y.; Cao, R.J.; Ming, Z.Z.; Yang, W.C.; Yang, G.F.
    Pyrazolone-quinazolone hybrids a novel class of human 4-hydroxyphenylpyruvate dioxygenase inhibitors (2014), Bioorg. Med. Chem., 22, 5194-5211 .
    View publication on PubMed

Application

EC Number Application Comment Organism
1.13.11.27 drug development the enzyme is an important target for treating type I tyrosinemia and alkaptonuria due to its significant role in tyrosine catabolism Homo sapiens
1.13.11.27 medicine compounds N-(4-methoxyphenyl)-7-nitro-2,1,3-benzoxadiazol-4-amine and 3-(2-bromo-4-methylphenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one can be potentially useful for the treatment of type I tyrosinemia and other diseases with defects in tyrosine degradation Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.27 gene HPD, recombinant expression of His6-tagged enzyme in Escherichia coli strain BL21(DE3) Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.27 3-(2,4-dimethylphenyl)-6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(2,4-dimethylphenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(2-bromo-4-methylphenyl)-6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(2-bromo-4-methylphenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(2-bromophenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(2-chloro-4-methylphenyl)-6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(2-chloro-4-methylphenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(2-chlorophenyl)-6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(2-chlorophenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(2-fluoro-4-methylphenyl)-6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(2-fluoro-4-methylphenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(2-fluorophenyl)-6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(2-fluorophenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(3,4-dichlorophenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(3-bbromophenyl)-6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(3-bromophenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(3-chlorophenyl)-6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(3-chlorophenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(3-fluorophenyl)-6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(3-fluorophenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(4-bromophenyl)-6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(4-bromophenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(4-chloro-2-methylphenyl)-6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(4-chloro-2-methylphenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(4-chlorophenyl)-6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(4-chlorophenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(4-fluoro-2-methylphenyl)-6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(4-fluoro-2-methylphenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(4-fluorophenyl)-6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 3-(4-fluorophenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methyl-3-m-tolylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methyl-3-o-tolylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methyl-3-p-tolylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-3-(2-methoxyphenyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-3-(4-methoxyphenyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methyl-3-(3-(trifluoromethoxy)phenyl) quinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methyl-3-(4-(trifluoromethoxy)phenyl) quinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methyl-3-m-tolylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methyl-3-o-tolylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methyl-3-p-tolylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methyl-3-phenylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-3-(2-methoxyphenyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-3-(3-methoxyphenyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-3-(4-methoxyphenyl)-2-methylquinazolin-4(3H)-one
-
 Homo sapiens
1.13.11.27 additional information structure-based design of a series of pyrazolone-quinazolone hybrids, as a class of human 4-hydroxyphenylpyruvate dioxygenase inhibitors, synthesis, overview. Molecular modeling indicates that the interaction between the pyrazolone ring and ferrous ion, and the hydrophobic interaction of quinazolone with its surrounding residues, such as Phe347 and Phe364, contribute greatly to the high potency of these inhibitors. Compounds N-(4-methoxyphenyl)-7-nitro-2,1,3-benzoxadiazol-4-amine and 3-(2-bromo-4-methylphenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one can be potentially useful for the treatment of type I tyrosinemia and other diseases with defects in tyrosine degradation Homo sapiens
1.13.11.27 nitisinone NBTC, in clinical use Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.13.11.27 Fe2+ a Fe(II)-dependent non-heme oxygenase Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.27 4-hydroxyphenylpyruvate + O2 Homo sapiens
-
 homogentisate + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.27 Homo sapiens P32754
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.13.11.27 recombinant His6-tagged enzyme from Escherichia coli strain BL21(DE3) by nickel affinity chromatography and ultrafiltration Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.27 4-hydroxyphenylpyruvate + O2
-
 Homo sapiens homogentisate + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.27 HPD
-
 Homo sapiens
1.13.11.27 HPPD
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.13.11.27 30
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.13.11.27 7
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.13.11.27 additional information
-
 additional information inhibition kinetics Homo sapiens
1.13.11.27 0.00001
-
 3-(3-chlorophenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000011
-
 3-(2-bromo-4-methylphenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000013
-
 6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methyl-3-m-tolylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000014
-
 3-(3-bromophenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000015
-
 3-(2-fluorophenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000018
-
 3-(4-bromophenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000019
-
 6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methyl-3-phenylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.00002
-
 3-(3-fluorophenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000022
-
 3-(2-chlorophenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000022
-
 3-(4-chlorophenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000024
-
 3-(2-bromophenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000025
-
 6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methyl-3-p-tolylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000025
-
 3-(3,4-dichlorophenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000031
-
 6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methyl-3-(3-(trifluoromethoxy)phenyl) quinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000032
-
 3-(4-chloro-2-methylphenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000034
-
 6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-3-(3-methoxyphenyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000034
-
 3-(4-fluorophenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000037
-
 nitisinone pH 7.0, 30°C, recombinant His-tagged enzyme Homo sapiens
1.13.11.27 0.000038
-
 6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-3-(2-methoxyphenyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.00004
-
 3-(4-fluoro-2-methylphenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000058
-
 6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methyl-3-o-tolylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000059
-
 3-(2,4-dimethylphenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.00006
-
 6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-3-(4-methoxyphenyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000074
-
 6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methyl-3-m-tolylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000079
-
 3-(2-fluorophenyl)-6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000081
-
 3-(2-fluoro-4-methylphenyl)-6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000086
-
 3-(2-chlorophenyl)-6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000087
-
 3-(2-bromo-4-methylphenyl)-6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.00009
-
 3-(3-fluorophenyl)-6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.00009
-
 3-(2-chloro-4-methylphenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000093
-
 3-(3-bbromophenyl)-6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000109
-
 3-(2-chloro-4-methylphenyl)-6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.00013
-
 3-(4-bromophenyl)-6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000156
-
 6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methyl-3-p-tolylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.00016
-
 6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methyl-3-(4-(trifluoromethoxy)phenyl) quinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000161
-
 3-(2,4-dimethylphenyl)-6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.00017
-
 3-(2-fluoro-4-methylphenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000173
-
 3-(3-chlorophenyl)-6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000177
-
 3-(4-chloro-2-methylphenyl)-6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000207
-
 6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-3-(2-methoxyphenyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000219
-
 3-(4-fluoro-2-methylphenyl)-6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000237
-
 3-(4-chlorophenyl)-6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000238
-
 6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-3-(4-methoxyphenyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000247
-
 3-(4-fluorophenyl)-6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens
1.13.11.27 0.000248
-
 6-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-2-methyl-3-o-tolylquinazolin-4(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C Homo sapiens