Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Sainsbury, P.D.; Mineyeva, Y.; Mycroft, Z.; Bugg, T.D.
    Chemical intervention in bacterial lignin degradation pathways development of selective inhibitors for intradiol and extradiol catechol dioxygenases (2015), Bioorg. Chem., 60, 102-109 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.3 (2E)-3-(3,4-dimethoxyphenyl)-N-hydroxyprop-2-enamide over 90% inhibition at 0.2 mM Rhodococcus jostii
1.13.11.3 (2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide over 90% inhibition at 0.2 mM Rhodococcus jostii
1.13.11.3 2-(2H-1,3-benzodioxol-5-yl)-N-[(4-fluorophenyl)methyl]-N-hydroxyacetamide 60% inhibition at 0.2 mM Rhodococcus jostii
1.13.11.3 3-(3,4-dimethoxyphenyl)-N-hydroxy-N-octylpropanamide 57% inhibition at 0.2 mM Rhodococcus jostii
1.13.11.3 3-(3,4-dimethoxyphenyl)-N-hydroxypropanamide 60% inhibition at 0.2 mM Rhodococcus jostii
1.13.11.3 additional information poor inhibition by N-hydroxy-3-(4-methoxyphenyl)propanamide at 0.2 mM Rhodococcus jostii
1.13.11.16 2-(3,4-dihydroxyphenyl)-N-[(4-fluorophenyl)methyl]-N-hydroxyacetamide over 90% inhibition at 0.25 mM Rhodococcus jostii
1.13.11.16 N-benzyl-3-(3,4-dimethoxyphenyl)-N-hydroxypropanamide 25% inhibition at 0.25 mM Rhodococcus jostii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.3 3,4-dihydroxybenzoate + O2 Rhodococcus jostii
-
 3-carboxy-cis,cis-muconate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.3 Rhodococcus jostii Q0SH27 AND Q0SH26 beta- and alpha-subunit
-
1.13.11.16 Rhodococcus jostii
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.3 3,4-dihydroxybenzoate + O2
-
 Rhodococcus jostii 3-carboxy-cis,cis-muconate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.3 3,4-PCD
-
 Rhodococcus jostii
1.13.11.3 protocatechuate 3,4-dioxygenase
-
 Rhodococcus jostii
1.13.11.16 2,3-dihydroxyphenylpropionate 1,2-dioxygenase
-
 Rhodococcus jostii
1.13.11.16 MhpB
-
 Rhodococcus jostii

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.13.11.3 37
-
 assay at Rhodococcus jostii
1.13.11.16 37
-
 assay at Rhodococcus jostii

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.13.11.3 7.5
-
 assay at Rhodococcus jostii
1.13.11.16 7.5
-
 assay at Rhodococcus jostii

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.13.11.3 0.015
-
 pH 7.5, 37°C Rhodococcus jostii (2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide
1.13.11.3 0.02
-
 pH 7.5, 37°C Rhodococcus jostii (2E)-3-(3,4-dimethoxyphenyl)-N-hydroxyprop-2-enamide
1.13.11.3 0.16
-
 pH 7.5, 37°C Rhodococcus jostii 3-(3,4-dimethoxyphenyl)-N-hydroxypropanamide
1.13.11.16 0.11
-
 pH 7.5, 37°C Rhodococcus jostii 2-(3,4-dihydroxyphenyl)-N-[(4-fluorophenyl)methyl]-N-hydroxyacetamide