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Literature summary extracted from

  • Vazquez-Zamorano, Z.E.; Gonzalez-Lopez, M.A.; Romero-Espejel, M.E.; Azuara-Liceaga, E.I.; Lopez-Casamichana, M.; Olivares-Trejo, J.d.e. .J.
    Streptococcus pneumoniae secretes a glyceraldehyde-3-phosphate dehydrogenase, which binds haemoglobin and haem (2014), Biometals, 27, 683-693 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.12 gene gapA, sequence comparisons Streptococcus pneumoniae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.12 extracellular the enzyme is secreted Streptococcus pneumoniae
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.12 38000
-
 native PAGE Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.12 D-glyceraldehyde 3-phosphate + phosphate + NAD+ Streptococcus pneumoniae
-
 3-phospho-D-glyceroyl phosphate + NADH + H+
-
 ?
1.2.1.12 additional information Streptococcus pneumoniae the enzyme binds hemoglobin and heme, it is a heme-binding protein ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.12 Streptococcus pneumoniae Q8CWN6
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.12 purification of the secreted protein from the secretome of iron-starved cells by heme affinity chromatography with enzyme elution through a 6 M guanidine hydrochloride solution Streptococcus pneumoniae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.12 D-glyceraldehyde 3-phosphate + phosphate + NAD+
-
 Streptococcus pneumoniae 3-phospho-D-glyceroyl phosphate + NADH + H+
-
 ?
1.2.1.12 additional information the enzyme binds hemoglobin and heme, it is a heme-binding protein Streptococcus pneumoniae ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.2.1.12 monomer 1 * 38000, SDS-PAGE, 1 * 38760, mass spectrometry Streptococcus pneumoniae
1.2.1.12 More enzyme modeling Streptococcus pneumoniae

Synonyms

EC Number Synonyms Comment Organism
1.2.1.12 GapA
-
 Streptococcus pneumoniae
1.2.1.12 GAPDH
-
 Streptococcus pneumoniae
1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase
-
 Streptococcus pneumoniae

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.12 NAD+
-
 Streptococcus pneumoniae

pI Value

EC Number Organism Comment pI Value Maximum pI Value
1.2.1.12 Streptococcus pneumoniae isoelectric focusing
-
 5.37

General Information

EC Number General Information Comment Organism
1.2.1.12 physiological function the enzyme of the human pathogen binds hemoglobin and heme, it is a heme-binding protein and might be playing a dynamic role in the success of the invasive and infective processes of this pathogen Streptococcus pneumoniae