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Literature summary extracted from

  • Moriya, S.S.; Miura, T.; Takao, K.; Sugita, Y.; Samejima, K.; Hiramatsu, K.; Kawakita, M.
    Development of irreversible inactivators of spermine oxidase and N1-acetylpolyamine oxidase (2014), Biol. Pharm. Bull., 37, 475-480 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.5.3.13 expressed in HEK 293 cells Homo sapiens
1.5.3.16 expressed in HEK 293 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.3.13 additional information no inhibitory activity: N-(3-aminopropyl)-N-2-propynyl-1,4-butanediamine and N-[3-(2-propynylamino)propyl]-1,4-butanediamine Homo sapiens
1.5.3.13 N,N-di-2,3-butadienyl-1,4-butanediamine i.e. MDL 72527, strong inhibition Homo sapiens
1.5.3.13 N-(3-aminopropyl)-N-2-propenyl-1,4-butanediamine moderate inhibition Homo sapiens
1.5.3.13 N-(3-aminopropyl)-N-2,3-butadienyl-1,4-butanediamine strong inhibition Homo sapiens
1.5.3.13 N-[3-(2,3-butadienylamino)propyl]-1,4-butanediamine strong inhibition Homo sapiens
1.5.3.13 N-[3-(2-propenylamino) propyl]-1,4-butanediamine moderate inhibition Homo sapiens
1.5.3.16 N-(3-aminopropyl)-N-2,3-butadienyl-1,4-butanediamine potent inhibition Homo sapiens
1.5.3.16 N-[3-(2,3-butadienylamino)propyl]-1,4-butanediamine moderate inhibition Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.3.13 N1-acetylspermidine + O2 + H2O Homo sapiens the enzyme is involved in polyamine catabolism. The enzyme is a constitutively expressed enzyme that catalyzes the oxidative cleavage of N1-acetylpolyamines to yield a less basic polyamine, 3-acetylamidopropanal, and hydrogen peroxide putrescine + 3-acetamidopropanal + H2O2
-
 ?
1.5.3.16 spermine + O2 + H2O Homo sapiens the enzyme is involved in polyamine catabolism. Highly inducible enzyme that catalyzes the oxidative cleavage of spermine to form spermidine, 3-aminopropanal, and hydrogen peroxide spermidine + 3-aminopropanal + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.3.13 Homo sapiens
-
-
-
1.5.3.16 Homo sapiens Q9NWM0
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.3.13 N1-acetylspermidine + O2 + H2O
-
 Homo sapiens putrescine + 3-acetamidopropanal + H2O2
-
 ?
1.5.3.13 N1-acetylspermidine + O2 + H2O the enzyme is involved in polyamine catabolism. The enzyme is a constitutively expressed enzyme that catalyzes the oxidative cleavage of N1-acetylpolyamines to yield a less basic polyamine, 3-acetylamidopropanal, and hydrogen peroxide Homo sapiens putrescine + 3-acetamidopropanal + H2O2
-
 ?
1.5.3.16 spermine + O2 + H2O
-
 Homo sapiens spermidine + 3-aminopropanal + H2O2
-
 ?
1.5.3.16 spermine + O2 + H2O the enzyme is involved in polyamine catabolism. Highly inducible enzyme that catalyzes the oxidative cleavage of spermine to form spermidine, 3-aminopropanal, and hydrogen peroxide Homo sapiens spermidine + 3-aminopropanal + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.5.3.13 APAO
-
 Homo sapiens
1.5.3.16 SMO
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.5.3.13 37
-
 assay at Homo sapiens
1.5.3.16 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.5.3.13 9
-
 assay at Homo sapiens
1.5.3.16 9
-
 assay at Homo sapiens

General Information

EC Number General Information Comment Organism
1.5.3.13 metabolism the enzyme is involved in polyamine catabolism Homo sapiens
1.5.3.16 metabolism the enzyme is involved in polyamine catabolism Homo sapiens