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Literature summary extracted from

  • Kitamura, T.; Takagi, S.; Naganuma, T.; Kihara, A.
    Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification (2015), Biochem. J., 465, 79-87 .
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.48 lipid droplet
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 Mus musculus 5811
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1.2.1.48 additional information the C-terminal regions, particularly the two tryptophan residues (Trp462 and Trp469) of isozyme ALDH3B2 and the two arginine residues (Arg462 and Arg463) of isozyme ALDH3B3, are important for the determination of their specific localization Mus musculus
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1.2.1.48 plasma membrane
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 Mus musculus 5886
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Organism

EC Number Organism UniProt Comment Textmining
1.2.1.48 Mus musculus E9Q3E1
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1.2.1.48 Mus musculus J3QMK6
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-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.2.1.48 lipoprotein enzyme ALDH3B2 is modified by prenylation at its C-terminus. The modification greatly influences its membrane localization and enzymatic activity towards hexadecanal Mus musculus
1.2.1.48 lipoprotein enzyme ALDH3B3 is modified by prenylation at its C-terminus. The modification greatly influences its membrane localization and enzymatic activity towards hexadecanal Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.48 hexadecanal + NAD+ + H2O
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 Mus musculus hexadecanoate + NADH + 2 H+
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 ?
1.2.1.48 additional information the enzyme ALDH3B2 exhibits broad substrate preferences from medium- to long-chain aldehydes Mus musculus ?
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 ?
1.2.1.48 additional information the enzyme ALDH3B3 exhibits broad substrate preferences from medium- to long-chain aldehydes Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.48 ALDH3B2
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 Mus musculus
1.2.1.48 ALDH3B3
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 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.48 NAD+
-
 Mus musculus

General Information

EC Number General Information Comment Organism
1.2.1.48 evolution the enzyme is a member of the ALDH3 family Mus musculus
1.2.1.48 physiological function ALDH3 family members (ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2 and ALDH3B3) are responsible for the removal of lipid-derived aldehydes Mus musculus
1.2.1.48 physiological function ALDH3 family members (ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2 and ALDH3B3) are responsible for the removal of lipid-derived aldehydes. Isozyme ALDH3B2 probably acts to remove lipid-derived aldehydes in lipid droplets generated via oxidative stress as a quality control mechanism Mus musculus