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Literature summary extracted from

  • Whitelaw, D.A.; Tonkin, R.; Meints, C.E.; Wolthers, K.R.
    Kinetic analysis of electron flux in cytochrome P450 reductases reveals differences in rate-determining steps in plant and mammalian enzymes (2015), Arch. Biochem. Biophys., 584, 107-115 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.2.4 2',5'-ADP
-
 Arabidopsis thaliana
1.6.2.4 2',5'-ADP
-
 Artemisia annua
1.6.2.4 2',5'-ADP
-
 Homo sapiens
1.6.2.4 NADP+
-
 Arabidopsis thaliana
1.6.2.4 NADP+
-
 Artemisia annua
1.6.2.4 NADP+
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.6.2.4 0.00071
-
 NADPH at pH 7.5 and 25°C Homo sapiens
1.6.2.4 0.00102
-
 NADPH at pH 7.5 and 25°C Arabidopsis thaliana
1.6.2.4 0.0086
-
 NADPH at pH 7.5 and 25°C Artemisia annua

Organism

EC Number Organism UniProt Comment Textmining
1.6.2.4 Arabidopsis thaliana
-
-
-
1.6.2.4 Artemisia annua
-
-
-
1.6.2.4 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.2.4 NADPH + H+ + ferricyanide
-
 Homo sapiens NADP+ + ferrocyanide
-
 ?
1.6.2.4 NADPH + H+ + ferricyanide
-
 Arabidopsis thaliana NADP+ + ferrocyanide
-
 ?
1.6.2.4 NADPH + H+ + ferricyanide
-
 Artemisia annua NADP+ + ferrocyanide
-
 ?
1.6.2.4 NADPH + H+ + ferricytochrome c
-
 Homo sapiens NADP+ + ferrocytochrome c
-
 ?
1.6.2.4 NADPH + H+ + ferricytochrome c
-
 Arabidopsis thaliana NADP+ + ferrocytochrome c
-
 ?
1.6.2.4 NADPH + H+ + ferricytochrome c
-
 Artemisia annua NADP+ + ferrocytochrome c
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.6.2.4 ATR2
-
 Arabidopsis thaliana
1.6.2.4 CPR
-
 Homo sapiens
1.6.2.4 CPR
-
 Artemisia annua
1.6.2.4 cytochrome P450 reductase
-
 Homo sapiens
1.6.2.4 cytochrome P450 reductase
-
 Arabidopsis thaliana
1.6.2.4 cytochrome P450 reductase
-
 Artemisia annua

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.6.2.4 2 3.7 ferricytochrome c at pH 7.5 and 25°C Arabidopsis thaliana
1.6.2.4 20
-
 ferricytochrome c at pH 7.5 and 25°C Homo sapiens
1.6.2.4 26.4
-
 ferricyanide at pH 7.5 and 25°C Homo sapiens
1.6.2.4 51.4
-
 ferricytochrome c at pH 7.5 and 25°C Artemisia annua
1.6.2.4 146
-
 ferricyanide at pH 7.5 and 25°C Arabidopsis thaliana
1.6.2.4 169
-
 ferricyanide at pH 7.5 and 25°C Artemisia annua

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.2.4 FAD
-
 Homo sapiens
1.6.2.4 FAD
-
 Arabidopsis thaliana
1.6.2.4 FAD
-
 Artemisia annua
1.6.2.4 FMN
-
 Homo sapiens
1.6.2.4 FMN
-
 Arabidopsis thaliana
1.6.2.4 FMN
-
 Artemisia annua

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.6.2.4 0.00056
-
 2',5'-ADP at pH 7.5 and 25°C Homo sapiens
1.6.2.4 0.00056
-
 2',5'-ADP at pH 7.5 and 25°C Arabidopsis thaliana
1.6.2.4 0.00071
-
 NADP+ at pH 7.5 and 25°C Homo sapiens
1.6.2.4 0.00091
-
 2',5'-ADP at pH 7.5 and 25°C Artemisia annua
1.6.2.4 0.00102
-
 NADP+ at pH 7.5 and 25°C Arabidopsis thaliana
1.6.2.4 0.0086
-
 NADP+ at pH 7.5 and 25°C Artemisia annua