Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Huang, J.; Smith, F.; Panizzi, P.
    Ordered cleavage of myeloperoxidase ester bonds releases active site heme leading to inactivation of myeloperoxidase by benzoic acid hydrazide analogs (2014), Arch. Biochem. Biophys., 548, 74-85 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.11.2.2 2-aminobenzoic acid hydrazide
-
Homo sapiens
1.11.2.2 3-(dimethylamino) benzoic acid hydrazide
-
Homo sapiens
1.11.2.2 4-(trifluoromethyl) benzoic acid hydrazide
-
Homo sapiens
1.11.2.2 4-amino benzoic acid hydrazide
-
Homo sapiens
1.11.2.2 4-fluorobenzoic acid hydrazide
-
Homo sapiens
1.11.2.2 4-nitrobenzoic acid hydrazide
-
Homo sapiens
1.11.2.2 benzoic acid hydrazide
-
Homo sapiens
1.11.2.2 isoniazid
-
Homo sapiens
1.11.2.2 NaN3
-
Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.11.2.2 0.031
-
10-acetyl-3,7-dihydroxyphenoxazine at pH 5.6 and 25°C Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.11.2.2 Cl- + H2O2 + H+ Homo sapiens
-
HClO + H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.11.2.2 Homo sapiens P05164
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.2.2 10-acetyl-3,7-dihydroxyphenoxazine + H2O2 + H+
-
Homo sapiens resorufin + H2O
-
?
1.11.2.2 Cl- + H2O2 + H+
-
Homo sapiens HClO + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.11.2.2 MPO
-
Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.11.2.2 186
-
10-acetyl-3,7-dihydroxyphenoxazine at pH 5.6 and 25°C Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.11.2.2 heme
-
Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.11.2.2 0.00024
-
4-amino benzoic acid hydrazide at pH 5.6 and 25°C Homo sapiens
1.11.2.2 0.00026
-
2-aminobenzoic acid hydrazide at pH 5.6 and 25°C Homo sapiens
1.11.2.2 0.00056
-
3-(dimethylamino) benzoic acid hydrazide at pH 5.6 and 25°C Homo sapiens
1.11.2.2 0.00069
-
benzoic acid hydrazide at pH 5.6 and 25°C Homo sapiens
1.11.2.2 0.00083
-
4-fluorobenzoic acid hydrazide at pH 5.6 and 25°C Homo sapiens
1.11.2.2 0.00084
-
NaN3 at pH 5.6 and 25°C Homo sapiens
1.11.2.2 0.00308
-
4-(trifluoromethyl) benzoic acid hydrazide at pH 5.6 and 25°C Homo sapiens
1.11.2.2 0.0037
-
4-nitrobenzoic acid hydrazide at pH 5.6 and 25°C Homo sapiens
1.11.2.2 0.01
-
isoniazid at pH 5.6 and 25°C Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.11.2.2 0.0005
-
at pH 5.6 and 25°C Homo sapiens 2-aminobenzoic acid hydrazide
1.11.2.2 0.00071
-
at pH 5.6 and 25°C Homo sapiens 4-amino benzoic acid hydrazide
1.11.2.2 0.00127
-
at pH 5.6 and 25°C Homo sapiens 3-(dimethylamino) benzoic acid hydrazide
1.11.2.2 0.00657
-
at pH 5.6 and 25°C Homo sapiens NaN3
1.11.2.2 0.02245
-
at pH 5.6 and 25°C Homo sapiens 4-fluorobenzoic acid hydrazide
1.11.2.2 0.04083
-
at pH 5.6 and 25°C Homo sapiens benzoic acid hydrazide
1.11.2.2 0.05462
-
at pH 5.6 and 25°C Homo sapiens 4-nitrobenzoic acid hydrazide
1.11.2.2 0.1427
-
at pH 5.6 and 25°C Homo sapiens 4-(trifluoromethyl) benzoic acid hydrazide
1.11.2.2 0.2771
-
at pH 5.6 and 25°C Homo sapiens isoniazid