EC Number | Cloned (Comment) | Organism |
---|---|---|
1.14.13.8 | expressed in Escherichia coli JM109 cells | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.13.8 | Benzydamine | i.e. 3-(1-benzyl-1H-indazol-3-yloxy)-N,N-dimethylpropan-1-amine, 47% inhibition at 1 mM | Homo sapiens | |
1.14.13.8 | clomiphene | i.e. 2-[4-[2-chloro-1,2-diphenylethenyl]phenoxy]-N,N-diethylethanamine, 60% inhibition at 0.05 mM | Homo sapiens | |
1.14.13.8 | selegiline | i.e. (2R)-N-methyl-1-phenyl-N-prop-2-ynylpropan-2-amine, 21% inhibition at 0.1 mM | Homo sapiens | |
1.14.13.8 | tamoxifen | i.e. (Z)-2-[4-(1,2-diphenylbut-1-enyl)phenoxy]-N,N-dimethylethanamine, 55% inhibition at 1 mM | Homo sapiens | |
1.14.13.8 | tozasertib | i.e. N-[4-[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin2yl]sulfanylphenyl]cyclopropane carboxamide, 41% inhibition at 0.1 mM | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.13.8 | 0.005 | - |
tamoxifen | pH and temperature not specified in the publication | Homo sapiens | |
1.14.13.8 | 0.018 | - |
clomiphene | pH and temperature not specified in the publication | Homo sapiens | |
1.14.13.8 | 0.023 | - |
tozasertib | pH and temperature not specified in the publication | Homo sapiens | |
1.14.13.8 | 0.056 | - |
Benzydamine | pH and temperature not specified in the publication | Homo sapiens | |
1.14.13.8 | 0.314 | - |
selegiline | pH and temperature not specified in the publication | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.13.8 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.14.13.8 | nickel affinity column chromatography | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.13.8 | liver | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.13.8 | benzydamine + NADPH + H+ + O2 | i.e. 3-(1-benzyl-1H-indazol-3-yloxy)-N,N-dimethylpropan-1-amine | Homo sapiens | ? | - |
? | |
1.14.13.8 | clomiphene + NADPH + H+ + O2 | i.e. 2-[4-[2-chloro-1,2-diphenylethenyl]phenoxy]-N,N-diethylethanamine | Homo sapiens | ? | - |
? | |
1.14.13.8 | methimazole + NADPH + H+ + O2 | - |
Homo sapiens | methimazole S-oxide + NADP+ + H2O | - |
? | |
1.14.13.8 | selegiline + NADPH + H+ + O2 | i.e. (2R)-N-methyl-1-phenyl-N-prop-2-ynylpropan-2-amine | Homo sapiens | ? | - |
? | |
1.14.13.8 | tamoxifen + NADPH + H+ + O2 | i.e. (Z)-2-[4-(1,2-diphenylbut-1-enyl)phenoxy]-N,N-dimethylethanamine | Homo sapiens | ? | - |
? | |
1.14.13.8 | tozasertib + NADPH + H+ + O2 | i.e. N-[4-[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin2yl]sulfanylphenyl]cyclopropane carboxamide | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.13.8 | flavin-containing monooxygenase 3 | - |
Homo sapiens |
1.14.13.8 | FMO3 | - |
Homo sapiens |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.13.8 | 0.0017 | - |
clomiphene | pH and temperature not specified in the publication | Homo sapiens | |
1.14.13.8 | 0.023 | - |
selegiline | pH and temperature not specified in the publication | Homo sapiens | |
1.14.13.8 | 0.15 | - |
Benzydamine | pH and temperature not specified in the publication | Homo sapiens | |
1.14.13.8 | 0.155 | - |
tozasertib | pH and temperature not specified in the publication | Homo sapiens | |
1.14.13.8 | 0.273 | - |
tamoxifen | pH and temperature not specified in the publication | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.14.13.8 | FAD | - |
Homo sapiens | |
1.14.13.8 | NADPH | - |
Homo sapiens |