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Literature summary extracted from

  • Bowser, T.E.; Trawick, M.L.
    Probing the specificity of gamma-glutamylamine cyclotransferase an enzyme involved in the metabolism of transglutaminase-catalyzed protein crosslinks (2013), Amino Acids, 44, 143-150 .
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.3.2.8 0.084
-
L-gamma-glutamylcyclopentylamine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.091
-
S-(n-butylcarbamyl)-L-cysteine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.12
-
L-gamma-glutamylneohexylamine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.19
-
S-(cyclohexylamine)-L-cysteine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.25
-
L-gamma-glutamyl-n-butylamine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.26
-
Nepsilon-(L-gamma-glutamyl)-L-lysine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.27
-
Nepsilon-(L-gamma-glutamyl)-D-lysine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.32
-
L-gamma-glutamyl-n-propylamine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.38
-
L-gamma-glutamyl-(2S)-2-methylbutylamine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.38
-
L-gamma-glutamyl-2-methylbutylamine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.56
-
L-gamma-glutamylbenzylamine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.91
-
L-gamma-glutamyl-beta-alanine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
4.3.2.8 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.3.2.8 kidney
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.2.8 L-gamma-glutamyl-(2S)-2-methylbutylamine
-
Oryctolagus cuniculus (2S)-2-methylbutylamine + 5-oxo-L-proline
-
?
4.3.2.8 L-gamma-glutamyl-2-methylbutylamine
-
Oryctolagus cuniculus 2-methylbutylamine + 5-oxo-L-proline
-
?
4.3.2.8 L-gamma-glutamyl-beta-alanine
-
Oryctolagus cuniculus beta-alanine + 5-oxo-L-proline
-
?
4.3.2.8 L-gamma-glutamyl-n-butylamine
-
Oryctolagus cuniculus n-butylamine + 5-oxo-L-proline
-
?
4.3.2.8 L-gamma-glutamyl-n-propylamine
-
Oryctolagus cuniculus n-propylamine + 5-oxo-L-proline
-
?
4.3.2.8 L-gamma-glutamylbenzylamine
-
Oryctolagus cuniculus benzylamine + 5-oxo-L-proline
-
?
4.3.2.8 L-gamma-glutamylcyclopentylamine
-
Oryctolagus cuniculus cyclopentylamine + 5-oxo-L-proline
-
?
4.3.2.8 L-gamma-glutamylneohexylamine
-
Oryctolagus cuniculus neohexylamine + 5-oxo-L-proline
-
?
4.3.2.8 additional information introduction of a methyl or carboxylate group on the carbon adjacent to the side-chain amide nitrogen in L-gamma-glutamylamine substrates results in a dramatic decrease in activity Oryctolagus cuniculus ?
-
?
4.3.2.8 Nepsilon-(L-gamma-glutamyl)-D-lysine
-
Oryctolagus cuniculus D-lysine + 5-oxo-L-proline
-
?
4.3.2.8 Nepsilon-(L-gamma-glutamyl)-L-lysine
-
Oryctolagus cuniculus L-lysine + 5-oxo-L-proline
-
?
4.3.2.8 S-(cyclohexylamine)-L-cysteine
-
Oryctolagus cuniculus ?
-
?
4.3.2.8 S-(n-butylcarbamyl)-L-cysteine
-
Oryctolagus cuniculus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
4.3.2.8 GGACT
-
Oryctolagus cuniculus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.3.2.8 0.076
-
L-gamma-glutamylcyclopentylamine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.18
-
L-gamma-glutamyl-beta-alanine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.18
-
L-gamma-glutamylneohexylamine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.19
-
L-gamma-glutamyl-2-methylbutylamine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.2
-
Nepsilon-(L-gamma-glutamyl)-L-lysine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.21
-
L-gamma-glutamyl-n-butylamine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.21
-
L-gamma-glutamyl-(2S)-2-methylbutylamine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.23
-
L-gamma-glutamyl-n-propylamine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.25
-
Nepsilon-(L-gamma-glutamyl)-D-lysine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.26
-
S-(cyclohexylamine)-L-cysteine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.27
-
S-(n-butylcarbamyl)-L-cysteine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.4
-
L-gamma-glutamylbenzylamine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
4.3.2.8 0.19
-
L-gamma-glutamyl-beta-alanine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.51
-
L-gamma-glutamyl-2-methylbutylamine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.55
-
L-gamma-glutamyl-(2S)-2-methylbutylamine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.71
-
L-gamma-glutamylbenzylamine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.72
-
L-gamma-glutamyl-n-propylamine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.78
-
Nepsilon-(L-gamma-glutamyl)-L-lysine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.83
-
L-gamma-glutamyl-n-butylamine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.9
-
L-gamma-glutamylcyclopentylamine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 0.92
-
Nepsilon-(L-gamma-glutamyl)-D-lysine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 1.45
-
L-gamma-glutamylneohexylamine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 1.5
-
S-(cyclohexylamine)-L-cysteine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus
4.3.2.8 2.8
-
S-(n-butylcarbamyl)-L-cysteine pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus