BRENDA - Enzyme Database

The role of NAD+-dependent isocitrate dehydrogenase 3 subunit alpha in AFB1 induced liver lesion

Yang, C.; Fan, J.; Zhuang, Z.; Fang, Y.; Zhang, Y.; Wang, S.; Toxicol. Lett. 224, 371-379 (2014)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
1.1.1.41
IDH3alpha, DNA and amino acid sequence analysis and comparison
Homo sapiens
1.1.1.41
IDH3alpha, DNA and amino acid sequence analysis and comparison
Mus musculus
1.1.1.41
IDH3alpha, DNA and amino acid sequence analysis and comparison
Rattus norvegicus
Engineering
EC Number
Amino acid exchange
Commentary
Organism
1.1.1.41
additional information
enzyme overexpression, or enzyme downregulation by siRNA
Homo sapiens
1.1.1.41
additional information
enzyme overexpression, or enzyme downregulation by siRNA
Mus musculus
1.1.1.41
additional information
enzyme overexpression, or enzyme downregulation by siRNA
Rattus norvegicus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.1.1.41
mitochondrion
-
Homo sapiens
5739
-
1.1.1.41
mitochondrion
-
Mus musculus
5739
-
1.1.1.41
mitochondrion
-
Rattus norvegicus
5739
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.41
isocitrate + NAD+
Mus musculus
-
2-oxoglutarate + CO2 + NADH
-
-
?
1.1.1.41
isocitrate + NAD+
Rattus norvegicus
-
2-oxoglutarate + CO2 + NADH
-
-
?
1.1.1.41
isocitrate + NAD+
Homo sapiens
-
2-oxoglutarate + CO2 + NADH
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.41
Homo sapiens
P50213
-
-
1.1.1.41
Mus musculus
Q9D6R2
-
-
1.1.1.41
Rattus norvegicus
Q99NA5
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.41
AGS cell
-
Homo sapiens
-
1.1.1.41
BEL-7404 cell
-
Homo sapiens
-
1.1.1.41
brain
-
Homo sapiens
-
1.1.1.41
brain
-
Mus musculus
-
1.1.1.41
brain
-
Rattus norvegicus
-
1.1.1.41
Chang liver cell
-
Homo sapiens
-
1.1.1.41
heart
-
Homo sapiens
-
1.1.1.41
heart
-
Mus musculus
-
1.1.1.41
heart
-
Rattus norvegicus
-
1.1.1.41
HEK-293 cell
-
Homo sapiens
-
1.1.1.41
Hep-G2 cell
-
Homo sapiens
-
1.1.1.41
kidney
-
Homo sapiens
-
1.1.1.41
kidney
-
Mus musculus
-
1.1.1.41
kidney
-
Rattus norvegicus
-
1.1.1.41
liver
-
Homo sapiens
-
1.1.1.41
liver
-
Mus musculus
-
1.1.1.41
liver
-
Rattus norvegicus
-
1.1.1.41
lung
-
Homo sapiens
-
1.1.1.41
lung
-
Mus musculus
-
1.1.1.41
lung
-
Rattus norvegicus
-
1.1.1.41
additional information
ubiquitous tissue specific expression of isocitrate dehydrogenase 3alpha subunit
Homo sapiens
-
1.1.1.41
additional information
ubiquitous tissue specific expression of isocitrate dehydrogenase 3alpha subunit
Mus musculus
-
1.1.1.41
additional information
ubiquitous tissue specific expression of isocitrate dehydrogenase 3alpha subunit
Rattus norvegicus
-
1.1.1.41
skeletal muscle
-
Homo sapiens
-
1.1.1.41
skeletal muscle
-
Mus musculus
-
1.1.1.41
skeletal muscle
-
Rattus norvegicus
-
1.1.1.41
small intestine
-
Homo sapiens
-
1.1.1.41
small intestine
-
Mus musculus
-
1.1.1.41
small intestine
-
Rattus norvegicus
-
1.1.1.41
spleen
-
Homo sapiens
-
1.1.1.41
spleen
-
Mus musculus
-
1.1.1.41
spleen
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.41
isocitrate + NAD+
-
741458
Mus musculus
2-oxoglutarate + CO2 + NADH
-
-
-
?
1.1.1.41
isocitrate + NAD+
-
741458
Rattus norvegicus
2-oxoglutarate + CO2 + NADH
-
-
-
?
1.1.1.41
isocitrate + NAD+
-
741458
Homo sapiens
2-oxoglutarate + CO2 + NADH
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.41
NAD+
-
Homo sapiens
1.1.1.41
NAD+
-
Mus musculus
1.1.1.41
NAD+
-
Rattus norvegicus
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
1.1.1.41
IDH3alpha, DNA and amino acid sequence analysis and comparison
Homo sapiens
1.1.1.41
IDH3alpha, DNA and amino acid sequence analysis and comparison
Mus musculus
1.1.1.41
IDH3alpha, DNA and amino acid sequence analysis and comparison
Rattus norvegicus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.41
NAD+
-
Homo sapiens
1.1.1.41
NAD+
-
Mus musculus
1.1.1.41
NAD+
-
Rattus norvegicus
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
1.1.1.41
additional information
enzyme overexpression, or enzyme downregulation by siRNA
Homo sapiens
1.1.1.41
additional information
enzyme overexpression, or enzyme downregulation by siRNA
Mus musculus
1.1.1.41
additional information
enzyme overexpression, or enzyme downregulation by siRNA
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.1.1.41
mitochondrion
-
Homo sapiens
5739
-
1.1.1.41
mitochondrion
-
Mus musculus
5739
-
1.1.1.41
mitochondrion
-
Rattus norvegicus
5739
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.41
isocitrate + NAD+
Mus musculus
-
2-oxoglutarate + CO2 + NADH
-
-
?
1.1.1.41
isocitrate + NAD+
Rattus norvegicus
-
2-oxoglutarate + CO2 + NADH
-
-
?
1.1.1.41
isocitrate + NAD+
Homo sapiens
-
2-oxoglutarate + CO2 + NADH
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.41
AGS cell
-
Homo sapiens
-
1.1.1.41
BEL-7404 cell
-
Homo sapiens
-
1.1.1.41
brain
-
Homo sapiens
-
1.1.1.41
brain
-
Mus musculus
-
1.1.1.41
brain
-
Rattus norvegicus
-
1.1.1.41
Chang liver cell
-
Homo sapiens
-
1.1.1.41
heart
-
Homo sapiens
-
1.1.1.41
heart
-
Mus musculus
-
1.1.1.41
heart
-
Rattus norvegicus
-
1.1.1.41
HEK-293 cell
-
Homo sapiens
-
1.1.1.41
Hep-G2 cell
-
Homo sapiens
-
1.1.1.41
kidney
-
Homo sapiens
-
1.1.1.41
kidney
-
Mus musculus
-
1.1.1.41
kidney
-
Rattus norvegicus
-
1.1.1.41
liver
-
Homo sapiens
-
1.1.1.41
liver
-
Mus musculus
-
1.1.1.41
liver
-
Rattus norvegicus
-
1.1.1.41
lung
-
Homo sapiens
-
1.1.1.41
lung
-
Mus musculus
-
1.1.1.41
lung
-
Rattus norvegicus
-
1.1.1.41
additional information
ubiquitous tissue specific expression of isocitrate dehydrogenase 3alpha subunit
Homo sapiens
-
1.1.1.41
additional information
ubiquitous tissue specific expression of isocitrate dehydrogenase 3alpha subunit
Mus musculus
-
1.1.1.41
additional information
ubiquitous tissue specific expression of isocitrate dehydrogenase 3alpha subunit
Rattus norvegicus
-
1.1.1.41
skeletal muscle
-
Homo sapiens
-
1.1.1.41
skeletal muscle
-
Mus musculus
-
1.1.1.41
skeletal muscle
-
Rattus norvegicus
-
1.1.1.41
small intestine
-
Homo sapiens
-
1.1.1.41
small intestine
-
Mus musculus
-
1.1.1.41
small intestine
-
Rattus norvegicus
-
1.1.1.41
spleen
-
Homo sapiens
-
1.1.1.41
spleen
-
Mus musculus
-
1.1.1.41
spleen
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.41
isocitrate + NAD+
-
741458
Mus musculus
2-oxoglutarate + CO2 + NADH
-
-
-
?
1.1.1.41
isocitrate + NAD+
-
741458
Rattus norvegicus
2-oxoglutarate + CO2 + NADH
-
-
-
?
1.1.1.41
isocitrate + NAD+
-
741458
Homo sapiens
2-oxoglutarate + CO2 + NADH
-
-
-
?
Expression
EC Number
Organism
Commentary
Expression
1.1.1.41
Homo sapiens
aflatoxin B1, AFB1, upregulates the enzyme in vivo and in vitro, in cells and in the process of AFB1-induced liver lesion
up
1.1.1.41
Mus musculus
aflatoxin B1, AFB1, upregulates the enzyme in vivo and in vitro, in cells and in the process of AFB1-induced liver lesion
up
1.1.1.41
Rattus norvegicus
aflatoxin B1, AFB1, upregulates the enzyme in vivo and in vitro, in cells and in the process of AFB1-induced liver lesion
up
General Information
EC Number
General Information
Commentary
Organism
1.1.1.41
malfunction
overexpression of IDH3alpha increases the phosphorylation level of Akt (protein kinase B) and neutralizes the cellular toxicity induced by aflatoxin B1 (AFB1) or H2O2 and apoptosis induced by AFB1, while the reduced expression of IDH3alpha by siRNA decreases the phosphorylation, indicating that IDH3alpha plays important roles in the oxidative stress-induced PI3K/Akt pathway. AFB1 treatment can increase the expression of IDH3alpha, and the activated PI3K/Aktpathway by IDH3alpha eventually neutralizes the apoptosis induced by AFB1
Homo sapiens
1.1.1.41
malfunction
overexpression of IDH3alpha increases the phosphorylation level of Akt (protein kinase B) and neutralizes the cellular toxicity induced by aflatoxin B1 (AFB1) or H2O2 and apoptosis induced by AFB1, while the reduced expression of IDH3alpha by siRNA decreases the phosphorylation, indicating that IDH3alpha plays important roles in the oxidative stress-induced PI3K/Akt pathway. AFB1 treatment can increase the expression of IDH3alpha, and the activated PI3K/Akt pathway by IDH3alpha eventually neutralizes the apoptosis induced by AFB1
Mus musculus
1.1.1.41
malfunction
overexpression of IDH3alpha increases the phosphorylation level of Akt (protein kinase B) and neutralizes the cellular toxicity induced by aflatoxin B1 (AFB1) or H2O2 and apoptosis induced by AFB1, while the reduced expression of IDH3alpha by siRNA decreases the phosphorylation, indicating that IDH3alpha plays important roles in the oxidative stress-induced PI3K/Akt pathway. AFB1 treatment can increase the expression of IDH3alpha, and the activated PI3K/Aktpathway by IDH3alpha eventually neutralizes the apoptosis induced by AFB1
Rattus norvegicus
1.1.1.41
physiological function
IDH3alpha increases the phosphorylation level and activation of Akt (protein kinase B)
Homo sapiens
1.1.1.41
physiological function
IDH3alpha increases the phosphorylation level and activation of Akt (protein kinase B)
Mus musculus
1.1.1.41
physiological function
IDH3alpha increases the phosphorylation level and activation of Akt (protein kinase B)
Rattus norvegicus
General Information (protein specific)
EC Number
General Information
Commentary
Organism
1.1.1.41
malfunction
overexpression of IDH3alpha increases the phosphorylation level of Akt (protein kinase B) and neutralizes the cellular toxicity induced by aflatoxin B1 (AFB1) or H2O2 and apoptosis induced by AFB1, while the reduced expression of IDH3alpha by siRNA decreases the phosphorylation, indicating that IDH3alpha plays important roles in the oxidative stress-induced PI3K/Akt pathway. AFB1 treatment can increase the expression of IDH3alpha, and the activated PI3K/Aktpathway by IDH3alpha eventually neutralizes the apoptosis induced by AFB1
Homo sapiens
1.1.1.41
malfunction
overexpression of IDH3alpha increases the phosphorylation level of Akt (protein kinase B) and neutralizes the cellular toxicity induced by aflatoxin B1 (AFB1) or H2O2 and apoptosis induced by AFB1, while the reduced expression of IDH3alpha by siRNA decreases the phosphorylation, indicating that IDH3alpha plays important roles in the oxidative stress-induced PI3K/Akt pathway. AFB1 treatment can increase the expression of IDH3alpha, and the activated PI3K/Akt pathway by IDH3alpha eventually neutralizes the apoptosis induced by AFB1
Mus musculus
1.1.1.41
malfunction
overexpression of IDH3alpha increases the phosphorylation level of Akt (protein kinase B) and neutralizes the cellular toxicity induced by aflatoxin B1 (AFB1) or H2O2 and apoptosis induced by AFB1, while the reduced expression of IDH3alpha by siRNA decreases the phosphorylation, indicating that IDH3alpha plays important roles in the oxidative stress-induced PI3K/Akt pathway. AFB1 treatment can increase the expression of IDH3alpha, and the activated PI3K/Aktpathway by IDH3alpha eventually neutralizes the apoptosis induced by AFB1
Rattus norvegicus
1.1.1.41
physiological function
IDH3alpha increases the phosphorylation level and activation of Akt (protein kinase B)
Homo sapiens
1.1.1.41
physiological function
IDH3alpha increases the phosphorylation level and activation of Akt (protein kinase B)
Mus musculus
1.1.1.41
physiological function
IDH3alpha increases the phosphorylation level and activation of Akt (protein kinase B)
Rattus norvegicus
Expression (protein specific)
EC Number
Organism
Commentary
Expression
1.1.1.41
Homo sapiens
aflatoxin B1, AFB1, upregulates the enzyme in vivo and in vitro, in cells and in the process of AFB1-induced liver lesion
up
1.1.1.41
Mus musculus
aflatoxin B1, AFB1, upregulates the enzyme in vivo and in vitro, in cells and in the process of AFB1-induced liver lesion
up
1.1.1.41
Rattus norvegicus
aflatoxin B1, AFB1, upregulates the enzyme in vivo and in vitro, in cells and in the process of AFB1-induced liver lesion
up