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Literature summary extracted from

  • Ando, T.; Nishiyama, T.; Takizawa, I.; Ishizaki, F.; Miyashiro, Y.; Takeda, K.; Hara, N.; Tomita, Y.
    Dihydrotestosterone synthesis pathways from inactive androgen 5alpha-androstane-3beta,17beta-diol in prostate cancer cells: Inhibition of intratumoural 3beta-hydroxysteroid dehydrogenase activities by abiraterone (2016), Sci. Rep., 6, 32198.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.145 abiraterone
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.145 dehydroepiandrosterone + NAD+ Homo sapiens
-
 androst-5-en-3,17-dione + NADH + H+
-
 ?
1.1.1.145 DELTA5-androstenediol + NAD+ Homo sapiens
-
 testosterone + NADH + H+
-
 ?
1.1.1.145 epiandrosterone + NAD+ Homo sapiens
-
 5alpha-androstan-3,17-dione + NADH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.145 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.145 LNCaP cell
-
 Homo sapiens
-
1.1.1.145 prostate cancer cell
-
 Homo sapiens
-
1.1.1.145 VCaP cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.145 dehydroepiandrosterone + NAD+
-
 Homo sapiens androst-5-en-3,17-dione + NADH + H+
-
 ?
1.1.1.145 DELTA5-androstenediol + NAD+
-
 Homo sapiens testosterone + NADH + H+
-
 ?
1.1.1.145 epiandrosterone + NAD+
-
 Homo sapiens 5alpha-androstan-3,17-dione + NADH + H+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.145 3beta-HSD
-
 Homo sapiens
1.1.1.145 3beta-hydroxysteroid dehydrogenase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.145 NAD+
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.1.1.145 metabolism isoform 3bHSD2 interacts with the mitochondrial translocase, Tim50, to regulate progesterone and androstenedione formation Homo sapiens