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Literature summary extracted from

  • Domise, M.; Didier, S.; Marinangeli, C.; Zhao, H.; Chandakkar, P.; Buee, L.; Viollet, B.; Davies, P.; Marambaud, P.; Vingtdeux, V.
    AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo (2016), Sci. Rep., 6, 26758.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.26 AICAR
-
Mus musculus
2.7.11.26 AMP AMP-activated protein kinase Mus musculus
2.7.11.26 metformin
-
Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.26 compound C inhibits tau protein phosphorylation by AMPK Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.26 microtubule
-
Mus musculus 5874
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.26 Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.26 ATP + [tau-protein] Mus musculus AMPK is one of the main tau kinase phosphorylating tau at the epitopes Ser262/356 and Thr231 at basal conditions in neurons ADP + O-phospho-[tau-protein]
-
?
2.7.11.26 ATP + [tau-protein] Mus musculus C57BL6 AMPK is one of the main tau kinase phosphorylating tau at the epitopes Ser262/356 and Thr231 at basal conditions in neurons ADP + O-phospho-[tau-protein]
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.26 Mus musculus Q5EG47
-
-
2.7.11.26 Mus musculus C57BL6 Q5EG47
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.26 brain the brain AMPK is mainly expressed in neurons Mus musculus
-
2.7.11.26 neuron primary neuronal cultures at 15 DIV Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.26 ATP + [tau-protein] AMPK is one of the main tau kinase phosphorylating tau at the epitopes Ser262/356 and Thr231 at basal conditions in neurons Mus musculus ADP + O-phospho-[tau-protein]
-
?
2.7.11.26 ATP + [tau-protein] AMPK phosphorylate tau in vitro at several epitopes including Thr231, Ser262/356, Ser396, Ser409 and Ser422, whereas Ser199, Ser202, Ser235, Ser400, and Ser404 are not phosphorylated by AMPK Mus musculus ADP + O-phospho-[tau-protein]
-
?
2.7.11.26 ATP + [tau-protein] AMPK is one of the main tau kinase phosphorylating tau at the epitopes Ser262/356 and Thr231 at basal conditions in neurons Mus musculus C57BL6 ADP + O-phospho-[tau-protein]
-
?
2.7.11.26 ATP + [tau-protein] AMPK phosphorylate tau in vitro at several epitopes including Thr231, Ser262/356, Ser396, Ser409 and Ser422, whereas Ser199, Ser202, Ser235, Ser400, and Ser404 are not phosphorylated by AMPK Mus musculus C57BL6 ADP + O-phospho-[tau-protein]
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.26 AMP-activated protein kinase
-
Mus musculus
2.7.11.26 AMPK
-
Mus musculus
2.7.11.26 tau kinase
-
Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.26 ATP
-
Mus musculus

General Information

EC Number General Information Comment Organism
2.7.11.26 malfunction AMPK inhibition leads to a rapid decrease of tau phosphorylation. AMP-activated protein kinase (AMPK) is deregulated in the Alzheimer's disease brain where it co-localized with phosphorylated tau in pre-tangle and tangle bearing neurons. AMPK mice deficient for one of the catalytic alpha subunits display reduced endogenous tau phosphorylation. AMPK deficiency reduces tau pathology in the PS19 mouse model of tauopathy Mus musculus
2.7.11.26 physiological function AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo. Tau functions, which include the regulation of microtubules dynamics, are dependent on its phosphorylation status, any changes in tau phosphorylation can have major impacts on synaptic plasticity and memory. Endogenous AMPK activation in mouse primary neurons induces an increase of tau at multiple sites. AMPK regulates tau phosphorylation in mouse primary neurons as well as in vivo, and thus suggest that AMPK could be a key player in the development of Alzheimer's disease pathology. The two alpha subunits of AMPK can have distinct roles. AMPKalpha2, which is the most highly expressed of the catalytic subunit in the brain, is responsible for the detrimental effects observed following ischemic stroke in mice. AMPK activation increases tau phosphorylation in primary neurons and affects tau binding to microtubules. AMPK controls basal tau phosphorylation levels Mus musculus