BRENDA - Enzyme Database

NAD-dependent isocitrate dehydrogenase as a novel target of tributyltin in human embryonic carcinoma cells

Yamada, S.; Kotake, Y.; Demizu, Y.; Kurihara, M.; Sekino, Y.; Kanda, Y.; Sci. Rep. 4, 5952 (2014)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
1.1.1.41
gene IDH3A, real-time PCR expression analysis
Homo sapiens
Engineering
EC Number
Amino acid exchange
Commentary
Organism
1.1.1.41
additional information
NAD-IDHalpha knockdown by shRNA
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.41
tributyltin
TBT, active in NT2/D1 carcinoma cells, overview. At nanomoler concentrations, tributyltin actions are mediated by genomic pathways via peroxisome proliferator-activated receptor gamma/retinoid X receptor, PPAR/RXR. Binding and in silico docking simulation analysis, overview
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.1.1.41
mitochondrion
-
Homo sapiens
5739
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.41
isocitrate + NAD+
Homo sapiens
-
2-oxoglutarate + CO2 + NADH
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.41
Homo sapiens
P50213
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.41
carcinoma cell
-
Homo sapiens
-
1.1.1.41
NT2/D1 cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.41
isocitrate + NAD+
-
741407
Homo sapiens
2-oxoglutarate + CO2 + NADH
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.41
NAD+
specific for
Homo sapiens
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
1.1.1.41
gene IDH3A, real-time PCR expression analysis
Homo sapiens
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.41
NAD+
specific for
Homo sapiens
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
1.1.1.41
additional information
NAD-IDHalpha knockdown by shRNA
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.41
tributyltin
TBT, active in NT2/D1 carcinoma cells, overview. At nanomoler concentrations, tributyltin actions are mediated by genomic pathways via peroxisome proliferator-activated receptor gamma/retinoid X receptor, PPAR/RXR. Binding and in silico docking simulation analysis, overview
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.1.1.41
mitochondrion
-
Homo sapiens
5739
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.41
isocitrate + NAD+
Homo sapiens
-
2-oxoglutarate + CO2 + NADH
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.41
carcinoma cell
-
Homo sapiens
-
1.1.1.41
NT2/D1 cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.41
isocitrate + NAD+
-
741407
Homo sapiens
2-oxoglutarate + CO2 + NADH
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
1.1.1.41
metabolism
NAD-IDH is a key enzyme in the tricarboxylic acid cycle
Homo sapiens
1.1.1.41
additional information
homology modeling and docking studies of the human NAD-IDHalpha, overview
Homo sapiens
General Information (protein specific)
EC Number
General Information
Commentary
Organism
1.1.1.41
metabolism
NAD-IDH is a key enzyme in the tricarboxylic acid cycle
Homo sapiens
1.1.1.41
additional information
homology modeling and docking studies of the human NAD-IDHalpha, overview
Homo sapiens