Literature summary extracted from

Kim, K.; Kim, H.; Yim, J.
Functional analysis of sepiapterin reductase in Drosophila melanogaster (2015), Pteridines, 26, 63-68.

No PubMed abstract available

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.153	Drosophila melanogaster	-	-	-

Synonyms

EC Number	Synonyms	Comment	Organism
1.1.1.153	sepiapterin reductase	-	Drosophila melanogaster

General Information

EC Number	General Information	Comment	Organism
1.1.1.153	malfunction	tetrahydrobiopterin deficiencies are implicated in neuronal disorders. Drosophile melanogastersloss-of-function enzyme mutants are resonsibel for hyposensitivityy to oxidative stress, enzyme activity and tetrahydrobiopterin levels in the mutants are significantly reduced compared to wild-type, while levels of phosphorylated Akt and total Akt protein are increased in the enzyme mutants	Drosophila melanogaster
1.1.1.153	metabolism	sepiapterin reductase is a key enzyme in the biosynthesis of tetrahydrobiopterin (BH4), an essential cofactor for the synthesis of important biogenic amines, including catecholamines and serotonin	Drosophila melanogaster
1.1.1.153	physiological function	sepiapterin reductase plays an important role in the Akt pathway	Drosophila melanogaster

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Release 2023.1 (January 2023)