EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.3.1.21 | endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
1.3.1.21 | membrane | - |
Homo sapiens | 16020 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.3.1.21 | 55000 | - |
x * 55000, SDS-PAGE | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.1.21 | cholesterol + NADP+ | Homo sapiens | - |
cholesta-5,7-dien-3beta-ol + NADPH + H+ | - |
? | |
1.3.1.21 | desmosterol + NADP+ | Homo sapiens | - |
7-dehydrodesmosterol + NADPH + H+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.3.1.21 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.1.21 | cholesterol + NADP+ | - |
Homo sapiens | cholesta-5,7-dien-3beta-ol + NADPH + H+ | - |
? | |
1.3.1.21 | desmosterol + NADP+ | - |
Homo sapiens | 7-dehydrodesmosterol + NADPH + H+ | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.3.1.21 | ? | x * 55000, SDS-PAGE | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.3.1.21 | Dhcr7 | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.3.1.21 | NADP+ | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.3.1.21 | malfunction | mutations in the enzyme gene lead to the developmental disease Smith-Lemli-Opitz syndrome which can also result in fetal mortality | Homo sapiens |
1.3.1.21 | metabolism | the enzyme exerts complex biological effects, involved in both cholesterol and vitamin D production | Homo sapiens |