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Literature summary extracted from

  • Louw-du Toit, R.; Perkins, M.S.; Snoep, J.L.; Storbeck, K.H.; Africander, D.
    Fourth-generation progestins inhibit 3beta-hydroxysteroid dehydrogenase type 2 and modulate the biosynthesis of endogenous steroids (2016), PLoS ONE, 11, e0164170.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.145 drospirenone
-
 Homo sapiens
1.1.1.145 nestorone
-
 Homo sapiens
1.1.1.145 nomegestrol acetate
-
 Homo sapiens
1.1.1.145 trilostane
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.145 17alpha-hydroxypregnenolone + NAD+ Homo sapiens
-
 17alpha-hydroxy-pregn-5-en-3,20-dione + NADH
-
 ?
1.1.1.145 dehydroepiandrosterone + NAD+ Homo sapiens
-
 androst-5-en-3,17-dione + NADH + H+
-
 ?
1.1.1.145 pregnenolone + NAD+ Homo sapiens
-
 pregn-5-en-3,20-dione + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.145 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.145 adrenocortical carcinoma cell
-
 Homo sapiens
-
1.1.1.145 H-295R cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.145 17alpha-hydroxypregnenolone + NAD+
-
 Homo sapiens 17alpha-hydroxy-pregn-5-en-3,20-dione + NADH
-
 ?
1.1.1.145 dehydroepiandrosterone + NAD+
-
 Homo sapiens androst-5-en-3,17-dione + NADH + H+
-
 ?
1.1.1.145 pregnenolone + NAD+
-
 Homo sapiens pregn-5-en-3,20-dione + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.145 3beta-hydroxysteroid dehydrogenase type 2 and
-
 Homo sapiens
1.1.1.145 3betaHSD2
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.145 NAD+
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.145 0.0000095
-
 nestorone pH and temperature not specified in the publication Homo sapiens
1.1.1.145 0.000029
-
 nomegestrol acetate pH and temperature not specified in the publication Homo sapiens
1.1.1.145 0.000031
-
 trilostane pH and temperature not specified in the publication Homo sapiens
1.1.1.145 0.000232
-
 drospirenone pH and temperature not specified in the publication Homo sapiens