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Literature summary extracted from

  • Chen, G.; Bai, Y.; Ren, L.; Zhu, D.; Li, Y.; Fang, M.; Al-Kateb, H.; Doran, O.
    Metabolism of androstenone, 17beta-estradiol and dihydrotestosterone in primary cultured pig hepatocytes and the role of 3beta-hydroxysteroid dehydrogenase in this process (2015), PLoS ONE, 10, e113194.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.145 trilostane specific inhibitor Sus scrofa
1.1.1.270 trilostane
-
 Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.145 androstenone + NAD+ Sus scrofa
-
 5alpha-androst-16-en-3beta-ol + NADH + H+
-
 ?
1.1.1.145 pregnenolone + NAD+ Sus scrofa
-
 pregn-5-en-3,20-dione + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.145 Sus scrofa
-
-
-
1.1.1.270 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.145 hepatocyte
-
 Sus scrofa
-
1.1.1.270 hepatocyte primary cultured hepatocyte Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.145 androstenone + NAD+
-
 Sus scrofa 5alpha-androst-16-en-3beta-ol + NADH + H+
-
 ?
1.1.1.145 pregnenolone + NAD+
-
 Sus scrofa pregn-5-en-3,20-dione + NADH + H+
-
 ?
1.1.1.270 androstenone + NAD(P)H + H+
-
 Sus scrofa 5alpha-androst-16-en-3beta-ol + NAD(P)+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.145 3-beta-hydroxysteroid dehydrogenase
-
 Sus scrofa
1.1.1.145 3betaHSD
-
 Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.145 NAD+
-
 Sus scrofa

General Information

EC Number General Information Comment Organism
1.1.1.145 metabolism isoform 3bHSD2 interacts with the mitochondrial translocase, Tim50, to regulate progesterone and androstenedione formation Sus scrofa
1.1.1.270 physiological function 3betaHSD is essential for metabolism of androstenone to 5alpha-androst-16-en-3beta-ol, which then forms androstenone glucuronide conjugate. 3betaHSD is not involved in 17beta-estradiol metabolism Sus scrofa