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Literature summary extracted from

  • Ni, H.; Sheng, X.; Cui, X.; Gu, M.; Liu, Y.; Qi, X.; Xing, S.; Guo, Y.
    Epidermal growth factor-mediated mitogen-activated protein kinase3/1 pathway is conducive to in vitro maturation of sheep oocytes (2015), PLoS ONE, 10, e0120418.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.24 additional information phosphorylation of the enzyme by MAPK kinase MEK activates the enzyme. U0126, a specific inhibitor of MEK (MAPK kinase), blocks the activation of MAPK3/1 and subsequently of EGF-mediated downstream MAPK3/1 pathway Ovis aries

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.24 additional information phosphorylation of the enzyme by MAPK kinase MEK activates the enzyme. U0126, a specific inhibitor of MEK (MAPK kinase), blocks the activation of MAPK3/1 and subsequently of EGF-mediated downstream MAPK3/1 pathway Ovis aries

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.24 Ovis aries W5P0L9
-
-
2.7.11.24 Ovis aries W5Q1R8
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.24 phosphoprotein phosphorylation of the enzyme by MAPK kinase MEK activates the enzyme Ovis aries

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.24 oocyte
-
 Ovis aries
-

Synonyms

EC Number Synonyms Comment Organism
2.7.11.24 ERK1
-
 Ovis aries
2.7.11.24 ERK2
-
 Ovis aries
2.7.11.24 MAPK1
-
 Ovis aries
2.7.11.24 MAPK3
-
 Ovis aries
2.7.11.24 mitogen-activated protein kinase 1
-
 Ovis aries
2.7.11.24 mitogen-activated protein kinase 3
-
 Ovis aries

General Information

EC Number General Information Comment Organism
2.7.11.24 physiological function effect of EGF-mediated mitogen-activated protein kinases 3 and 1 (MAPK3/1) pathway on in vitro cytoplasmic maturation of sheep oocytes, overview. The key downstream effectors of EGFR signaling in cumulus cells, mitogen-activated protein kinases 3 and 1 (MAPK3/1, also known as ERK1/2), is essential for mammalian oocyte maturation. Maturation of mammalian oocytes is a complex and dynamic process involving the maturation of nucleus and cytoplasm Ovis aries