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Literature summary extracted from

  • Qi, X.; Deng, W.; Gao, M.; Mao, B.; Xu, S.; Chen, C.; Zhang, Q.
    Novel lead compound optimization and synthesized based on the target structure of Xanthomonas oryzae pv. oryzae GlmU (2015), Pestic. Biochem. Physiol., 122, 22-28.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.7.23 drug development N-acetylglucosamine-1-phosphate uridyltransferase (GlmU) is an attractive target for the development of antimicrobial agents Xanthomonas oryzae pv. oryzae

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.23 additional information for development of potent and selective inhibitors of the uridyltransferase activity of Xanthomonas oryzae pv. oryzae GlmU, three types of target compounds are optimized and synthesized based on the Xo-GlmU structure, docking stud, and biological activity evaluation, overview Xanthomonas oryzae pv. oryzae
2.7.7.23 N1',N3'-bis(2-(1-bromonaphthalen naphthalen-2-yloxy)acetyl)isophthalohydrazide
-
 Xanthomonas oryzae pv. oryzae
2.7.7.23 N1',N3'-bis(2-(3-bromonaphthalen naphthalen-2-yloxy)acetyl)isophthalohydrazide
-
 Xanthomonas oryzae pv. oryzae
2.7.7.23 N1',N3'-bis(2-(6-bromonaphthalen naphthalen-2-yloxy)acetyl)isophthalohydrazide
-
 Xanthomonas oryzae pv. oryzae
2.7.7.23 N1',N3'-bis(2-(naphthalen-2-yloxy)acetyl) isophthalohydrazide
-
 Xanthomonas oryzae pv. oryzae
2.7.7.23 N1',N4'-bis(2-(1-bromonaphthalen naphthalen-2-yloxy)acetyl)succinohydrazide
-
 Xanthomonas oryzae pv. oryzae
2.7.7.23 N1',N4'-bis(2-(3-bromonaphthalen naphthalen-2-yloxy)acetyl)succinohydrazide
-
 Xanthomonas oryzae pv. oryzae
2.7.7.23 N1',N4'-bis(2-(6-bromonaphthalen naphthalen-2-yloxy)acetyl)succinohydrazide
-
 Xanthomonas oryzae pv. oryzae
2.7.7.23 N1',N4'-bis(2-(naphthalen-2-yloxy)acetyl) succinohydrazide
-
 Xanthomonas oryzae pv. oryzae
2.7.7.23 N1',N6'-bis(2-(1-bromonaphthalen naphthalen-2-yloxy)acetyl)adipohydrazide
-
 Xanthomonas oryzae pv. oryzae
2.7.7.23 N1',N6'-bis(2-(3-bromonaphthalen naphthalen-2-yloxy)acetyl)adipohydrazide
-
 Xanthomonas oryzae pv. oryzae
2.7.7.23 N1',N6'-bis(2-(6-bromonaphthalen naphthalen-2-yloxy)acetyl)adipohydrazide
-
 Xanthomonas oryzae pv. oryzae
2.7.7.23 N1',N6'-bis(2-(naphthalen-2-yloxy)acetyl)adipohydrazide
-
 Xanthomonas oryzae pv. oryzae

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.7.23 Mg2+ required Xanthomonas oryzae pv. oryzae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.23 UTP + N-acetyl-alpha-D-glucosamine 1-phosphate Xanthomonas oryzae pv. oryzae
-
 diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.23 Xanthomonas oryzae pv. oryzae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.23 UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 Xanthomonas oryzae pv. oryzae diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.23 GlmU
-
 Xanthomonas oryzae pv. oryzae
2.7.7.23 N-acetylglucosamine-1-phosphate uridyltransferase
-
 Xanthomonas oryzae pv. oryzae

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.7.23 37
-
 assay at Xanthomonas oryzae pv. oryzae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.7.23 7.5
-
 assay at Xanthomonas oryzae pv. oryzae

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.7.23 0.0108
-
 pH 7.5, 37°C Xanthomonas oryzae pv. oryzae N1',N3'-bis(2-(1-bromonaphthalen naphthalen-2-yloxy)acetyl)isophthalohydrazide
2.7.7.23 0.0112
-
 pH 7.5, 37°C Xanthomonas oryzae pv. oryzae N1',N4'-bis(2-(6-bromonaphthalen naphthalen-2-yloxy)acetyl)succinohydrazide
2.7.7.23 0.0125
-
 pH 7.5, 37°C Xanthomonas oryzae pv. oryzae N1',N6'-bis(2-(6-bromonaphthalen naphthalen-2-yloxy)acetyl)adipohydrazide
2.7.7.23 0.0134
-
 pH 7.5, 37°C Xanthomonas oryzae pv. oryzae N1',N3'-bis(2-(6-bromonaphthalen naphthalen-2-yloxy)acetyl)isophthalohydrazide
2.7.7.23 0.0138
-
 pH 7.5, 37°C Xanthomonas oryzae pv. oryzae N1',N3'-bis(2-(naphthalen-2-yloxy)acetyl) isophthalohydrazide
2.7.7.23 0.0154
-
 pH 7.5, 37°C Xanthomonas oryzae pv. oryzae N1',N4'-bis(2-(1-bromonaphthalen naphthalen-2-yloxy)acetyl)succinohydrazide
2.7.7.23 0.0171
-
 pH 7.5, 37°C Xanthomonas oryzae pv. oryzae N1',N4'-bis(2-(naphthalen-2-yloxy)acetyl) succinohydrazide
2.7.7.23 0.0184
-
 pH 7.5, 37°C Xanthomonas oryzae pv. oryzae N1',N3'-bis(2-(3-bromonaphthalen naphthalen-2-yloxy)acetyl)isophthalohydrazide
2.7.7.23 0.0194
-
 pH 7.5, 37°C Xanthomonas oryzae pv. oryzae N1',N4'-bis(2-(3-bromonaphthalen naphthalen-2-yloxy)acetyl)succinohydrazide
2.7.7.23 0.022
-
 pH 7.5, 37°C Xanthomonas oryzae pv. oryzae N1',N6'-bis(2-(3-bromonaphthalen naphthalen-2-yloxy)acetyl)adipohydrazide
2.7.7.23 0.0233
-
 pH 7.5, 37°C Xanthomonas oryzae pv. oryzae N1',N6'-bis(2-(1-bromonaphthalen naphthalen-2-yloxy)acetyl)adipohydrazide
2.7.7.23 0.0332
-
 pH 7.5, 37°C Xanthomonas oryzae pv. oryzae N1',N6'-bis(2-(naphthalen-2-yloxy)acetyl)adipohydrazide