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Literature summary extracted from

  • Sun, S.Q.; Gu, X.; Gao, X.S.; Li, Y.; Yu, H.; Xiong, W.; Yu, H.; Wang, W.; Li, Y.; Teng, Y.; Zhou, D.
    Overexpression of AKR1C3 significantly enhances human prostate cancer cells resistance to radiation (2016), Oncotarget, 7, 48050-48058.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.188 additional information establishment of a stable overexpressing AKR1C3 cell line (AKR1C3-over) derived from the prostate cell line DU145 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.188 indomethacin
-
 Homo sapiens
1.1.1.188 additional information combination of indomethacin with tert-butyl hydroperoxide significantly inhibits the growth of radiation-resistant AKR1C3-over cells Homo sapiens
1.1.1.188 tert-butyl hydroperoxide
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.188 Homo sapiens P42330
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.188 DU-145 cell
-
 Homo sapiens
-
1.1.1.188 prostate cancer cell
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
1.1.1.188 AKR1C3
-
 Homo sapiens
1.1.1.188 aldo-keto reductase 1C3
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.1.1.188 physiological function the enzyme is involved in prostaglandins metabolism. The produced PGF2alpha can not only promote prostate cancer cell's proliferation but also enhance prostate cancer cells resistance to radition. Overexpression of AKR1C3 significantly enhances human prostate cancer cells PCa resistance to radiation (or tert-butyl hydroperoxide) through activation of MAPK pathway. AKR1C3 has a pivotal role in the radioresistance of esophageal cancer and non-small-cell lung cancer Homo sapiens