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Literature summary extracted from

  • Kalita, R.; Patar, L.; Shasany, A.K.; Modi, M.K.; Sen, P.
    Molecular cloning, characterization and expression analysis of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene from Centella asiatica L. (2015), Mol. Biol. Rep., 42, 1431-1439.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.34 gene HMGR, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, subcloning in Escherichia coli strain DH5alpha Centella asiatica

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.34 58000
-
 x * 58000, about, sequence calculation Centella asiatica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.34 (R)-mevalonate + CoA + 2 NADP+ Centella asiatica
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.34 Centella asiatica W6APW1
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.34 leaf
-
 Centella asiatica
-
1.1.1.34 additional information the enzyme shows a strong expression in nodes followed by leaves and stem. Roots record the lowest expression level among all the tissues tested Centella asiatica
-
1.1.1.34 node
-
 Centella asiatica
-
1.1.1.34 root
-
 Centella asiatica
-
1.1.1.34 stem
-
 Centella asiatica
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.34 (R)-mevalonate + CoA + 2 NADP+
-
 Centella asiatica (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
 r

Subunits

EC Number Subunits Comment Organism
1.1.1.34 ? x * 58000, about, sequence calculation Centella asiatica

Synonyms

EC Number Synonyms Comment Organism
1.1.1.34 3-hydroxy-3-methylglutaryl coenzyme A reductase
-
 Centella asiatica
1.1.1.34 HMGR
-
 Centella asiatica

pI Value

EC Number Organism Comment pI Value Maximum pI Value
1.1.1.34 Centella asiatica sequence calculation
-
 8.65

General Information

EC Number General Information Comment Organism
1.1.1.34 additional information structure-function analysis of HMGR, homology modelling using human HMGR, PDB ID 1DQ8A, as template, overview Centella asiatica
1.1.1.34 physiological function the enzyme plays an important role in catalyzing the first committed step of isoprenoid biosynthesis in the mevalonic acid pathway catalyzing the conversion of HMG-CoA to mevalonic acid in plants Centella asiatica