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Literature summary extracted from

  • Ingram, A.K.; Cross, G.A.; Horn, D.
    Genetic manipulation indicates that ARD1 is an essential Nalpha-acetyltransferase in Trypanosoma brucei (2000), Mol. Biochem. Parasitol., 111, 309-317.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.255 27500
-
-
 Trypanosoma brucei

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.255 acetyl-CoA + an N-terminal-glycyl-[protein] Trypanosoma brucei
-
 an N-terminal-Nalpha-acetyl-glycyl-[protein] + CoA
-
 ?
2.3.1.255 acetyl-CoA + an N-terminal-glycyl-[protein] Trypanosoma brucei MiTat 427
-
 an N-terminal-Nalpha-acetyl-glycyl-[protein] + CoA
-
 ?
2.3.1.255 acetyl-CoA + an N-terminal-L-alanyl-[protein] Trypanosoma brucei
-
 an N-terminal-Nalpha-acetyl-L-alanyl-[protein] + CoA
-
 ?
2.3.1.255 acetyl-CoA + an N-terminal-L-alanyl-[protein] Trypanosoma brucei MiTat 427
-
 an N-terminal-Nalpha-acetyl-L-alanyl-[protein] + CoA
-
 ?
2.3.1.255 acetyl-CoA + an N-terminal-L-cysteinyl-[protein] Trypanosoma brucei
-
 an N-terminal-Nalpha-acetyl-L-cysteinyl-[protein] + CoA
-
 ?
2.3.1.255 acetyl-CoA + an N-terminal-L-cysteinyl-[protein] Trypanosoma brucei MiTat 427
-
 an N-terminal-Nalpha-acetyl-L-cysteinyl-[protein] + CoA
-
 ?
2.3.1.255 acetyl-CoA + an N-terminal-L-seryl-[protein] Trypanosoma brucei
-
 an N-terminal-Nalpha-acetyl-L-seryl-[protein] + CoA
-
 ?
2.3.1.255 acetyl-CoA + an N-terminal-L-seryl-[protein] Trypanosoma brucei MiTat 427
-
 an N-terminal-Nalpha-acetyl-L-seryl-[protein] + CoA
-
 ?
2.3.1.255 acetyl-CoA + an N-terminal-L-threonyl-[protein] Trypanosoma brucei
-
 an N-terminal-Nalpha-acetyl-L-threonyl-[protein] + CoA
-
 ?
2.3.1.255 acetyl-CoA + an N-terminal-L-threonyl-[protein] Trypanosoma brucei MiTat 427
-
 an N-terminal-Nalpha-acetyl-L-threonyl-[protein] + CoA
-
 ?
2.3.1.255 acetyl-CoA + an N-terminal-L-valyl-[protein] Trypanosoma brucei
-
 an N-terminal-Nalpha-acetyl-L-valyl-[protein] + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.255 Trypanosoma brucei Q9NFL8 catalytic subunit ARD1
-
2.3.1.255 Trypanosoma brucei MiTat 427 Q9NFL8 catalytic subunit ARD1
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.255 acetyl-CoA + an N-terminal-glycyl-[protein]
-
 Trypanosoma brucei an N-terminal-Nalpha-acetyl-glycyl-[protein] + CoA
-
 ?
2.3.1.255 acetyl-CoA + an N-terminal-glycyl-[protein]
-
 Trypanosoma brucei MiTat 427 an N-terminal-Nalpha-acetyl-glycyl-[protein] + CoA
-
 ?
2.3.1.255 acetyl-CoA + an N-terminal-L-alanyl-[protein]
-
 Trypanosoma brucei an N-terminal-Nalpha-acetyl-L-alanyl-[protein] + CoA
-
 ?
2.3.1.255 acetyl-CoA + an N-terminal-L-alanyl-[protein]
-
 Trypanosoma brucei MiTat 427 an N-terminal-Nalpha-acetyl-L-alanyl-[protein] + CoA
-
 ?
2.3.1.255 acetyl-CoA + an N-terminal-L-cysteinyl-[protein]
-
 Trypanosoma brucei an N-terminal-Nalpha-acetyl-L-cysteinyl-[protein] + CoA
-
 ?
2.3.1.255 acetyl-CoA + an N-terminal-L-cysteinyl-[protein]
-
 Trypanosoma brucei MiTat 427 an N-terminal-Nalpha-acetyl-L-cysteinyl-[protein] + CoA
-
 ?
2.3.1.255 acetyl-CoA + an N-terminal-L-seryl-[protein]
-
 Trypanosoma brucei an N-terminal-Nalpha-acetyl-L-seryl-[protein] + CoA
-
 ?
2.3.1.255 acetyl-CoA + an N-terminal-L-seryl-[protein]
-
 Trypanosoma brucei MiTat 427 an N-terminal-Nalpha-acetyl-L-seryl-[protein] + CoA
-
 ?
2.3.1.255 acetyl-CoA + an N-terminal-L-threonyl-[protein]
-
 Trypanosoma brucei an N-terminal-Nalpha-acetyl-L-threonyl-[protein] + CoA
-
 ?
2.3.1.255 acetyl-CoA + an N-terminal-L-threonyl-[protein]
-
 Trypanosoma brucei MiTat 427 an N-terminal-Nalpha-acetyl-L-threonyl-[protein] + CoA
-
 ?
2.3.1.255 acetyl-CoA + an N-terminal-L-valyl-[protein]
-
 Trypanosoma brucei an N-terminal-Nalpha-acetyl-L-valyl-[protein] + CoA
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.255 ? x * 27500, subunit ARD1, calculated from amino acid sequence Trypanosoma brucei

Synonyms

EC Number Synonyms Comment Organism
2.3.1.255 ARD1
-
 Trypanosoma brucei
2.3.1.255 ARD1-NAT1 Nalpha-acetyltransferase
-
 Trypanosoma brucei

General Information

EC Number General Information Comment Organism
2.3.1.255 physiological function ARD1 is essential for viability in mammalian and insect-stage Trypanosoma brucei cells Trypanosoma brucei