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Literature summary extracted from

  • Conger, M.A.; Pokhrel, D.; Liptak, M.D.
    Tight binding of heme to Staphylococcus aureus IsdG and IsdI precludes design of a competitive inhibitor (2017), Metallomics, 9, 556-563.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.48 Staphylococcus aureus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.48 additional information dissociation equilibrium constants of heme are 1.4 nM and 12.9 nM for isoforms IsdG and IsdI, respectively. Heme dissociation rate constants are 0.022 per s for IsdG and 0.092 per s for IsdI. It is proposed that only IsdG is a member of the heme iron acquisition pathway and IsdI regulates heme homeostasis Staphylococcus aureus ?
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1.14.99.48 protoheme + 5 reduced acceptor + 4 O2
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Staphylococcus aureus 15-oxo-beta-bilirubin + Fe2+ + formaldehyde + 5 acceptor + 4 H2O
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1.14.99.48 protoheme + 5 reduced acceptor + 4 O2
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Staphylococcus aureus 5-oxo-delta-bilirubin + Fe2+ + formaldehyde + 5 acceptor + 4 H2O
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