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Literature summary extracted from

  • San Jose, G.; Jackson, E.R.; Uh, E.; Johny, C.; Haymond, A.; Lundberg, L.; Pinkham, C.; Kehn-Hall, K.; Boshoff, H.I.; Couch, R.D.; Dowd, C.S.
    Design of potential bisubstrate inhibitors against Mycobacterium tuberculosis (Mtb) 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr) - evidence of a novel binding mode (2013), MedChemComm, 4, 1099-1104.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.267 additional information use of the Dxr-fosmidomycin cocrystal structure to design bisubstrate ligands to bind to both the 1-deoxy-D-xylulose-5-phosphate and NADPH sites Mycobacterium tuberculosis
1.1.1.267 [3-[hydroxy(3-phenylpropanoyl)amino]propyl]phosphonic acid compound binds to Dxr via a non-bisubstrate mechanism. The diethyl ester of [3-[hydroxy(3-phenylpropanoyl)amino]propyl]phosphonic acid inhibits Mycobacterium tuberculosis growth Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.267 Mycobacterium tuberculosis
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Synonyms

EC Number Synonyms Comment Organism
1.1.1.267 DXR
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 Mycobacterium tuberculosis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.267 0.0178
-
 pH not specified in the publication, temperature not specified in the publication Mycobacterium tuberculosis [3-[hydroxy(3-phenylpropanoyl)amino]propyl]phosphonic acid