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Literature summary extracted from

  • Srivilai, J.; Rabgay, K.; Khorana, N.; Waranuch, N.; Nuengchamnong, N.; Wisuitiprot, W.; Chuprajob, T.; Changtam, C.; Suksamrarn, A.; Chavasiri, W.; Sornkaew, N.; Ingkaninan, K.
    Anti-androgenic curcumin analogues as steroid 5-alpha reductase inhibitors (2017), Med. Chem. Res., 26, 1550-1556.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.22 bisdemethoxycurcumin 22.2% inhibition at 0.3 mM Homo sapiens
1.3.1.22 curcumin complete inhibition at 0.3 mM Homo sapiens
1.3.1.22 demethoxycurcumin complete inhibition at 0.3 mM Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.22 testosterone + NADPH + H+ Homo sapiens
-
 5alpha-dihydrotestosterone + NADP+
-
 ?
1.3.1.22 testosterone + NADPH + H+ Homo sapiens CRL-1740
-
 5alpha-dihydrotestosterone + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.22 Homo sapiens
-
-
-
1.3.1.22 Homo sapiens CRL-1740
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.22 LNCaP cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.22 testosterone + NADPH + H+
-
 Homo sapiens 5alpha-dihydrotestosterone + NADP+
-
 ?
1.3.1.22 testosterone + NADPH + H+
-
 Homo sapiens CRL-1740 5alpha-dihydrotestosterone + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.22 S5alphaR
-
 Homo sapiens
1.3.1.22 steroid 5-alpha reductase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.22 NADPH
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.3.1.22 0.0134
-
 at pH 7.4 and 37°C Homo sapiens curcumin
1.3.1.22 0.0225
-
 at pH 7.4 and 37°C Homo sapiens demethoxycurcumin
1.3.1.22 0.3
-
 at pH 7.4 and 37°C Homo sapiens bisdemethoxycurcumin