Any feedback?
Literature summary extracted from
- 11beta-Hydroxysteroid dehydrogenase 1: Regeneration of active glucocorticoids is only part of the story (2015), J. Steroid Biochem. Mol. Biol., 151, 85-92.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.146 | dihydrotestosterone | - |
Mus musculus |  |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.1.1.146 | endoplasmic reticulum | - |
Mus musculus | 5783 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.146 | cortisone + NADPH + H+ | Mus musculus | - |
cortisol + NADP+ | - |
r | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.146 | Mus musculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.146 | liver | - |
Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.146 | 11-dehydrocorticosterone + NADPH + H+ | - |
Mus musculus | corticosterone + NADP+ | - |
? | |
| 1.1.1.146 | 11-oxotestosterone + NADPH + H+ | - |
Mus musculus | ? | - |
? | |
| 1.1.1.146 | 4-nitroacetophenone + NADPH + H+ | - |
Mus musculus | ? | - |
? | |
| 1.1.1.146 | 4-nitrobenzaldehyde + NADPH + H+ | - |
Mus musculus | ? | - |
? | |
| 1.1.1.146 | 7-oxocholesterol + NADPH + H+ | - |
Mus musculus | 7alpha-hydroxycholesterol + NADP+ | - |
? | |
| 1.1.1.146 | 7-oxolithocholic acid + NADPH + H+ | - |
Mus musculus | ? | - |
? | |
| 1.1.1.146 | bupropion + NADPH + H+ | - |
Mus musculus | threohydrobupropion | - |
? | |
| 1.1.1.146 | cortisone + NADPH + H+ | - |
Mus musculus | cortisol + NADP+ | - |
r | |
| 1.1.1.146 | DFU-lactol + NADPH + H+ | - |
Mus musculus | ? | - |
? | |
| 1.1.1.146 | itrosamineketone + NADPH + H+ | - |
Mus musculus | ? | - |
? | |
| 1.1.1.146 | ketoprofen + NADPH + H+ | - |
Mus musculus | ? | - |
? | |
| 1.1.1.146 | metyrapone + NADPH + H+ | - |
Mus musculus | 7alpha-hydroxycholesterol + NADP+ | - |
? | |
| 1.1.1.146 | oracin + NADPH + H+ | - |
Mus musculus | ? | - |
? | |
| 1.1.1.146 | triadimefon + NADPH + H+ | - |
Mus musculus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.1.146 | 11beta-HSD1 | - |
Mus musculus |
| 1.1.1.146 | 11beta-hydroxysteroid dehydrogenase 1 | - |
Mus musculus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.146 | NAD+ | - |
Mus musculus | |
| 1.1.1.146 | NADPH | - |
Mus musculus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
