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Literature summary extracted from

  • Zou, L.; Porter, T.D.
    Rapid suppression of 7-dehydrocholesterol reductase activity in keratinocytes by vitamin D (2015), J. Steroid Biochem. Mol. Biol., 148, 64-71.
    View publication on PubMed

General Stability

EC Number General Stability Organism
1.3.1.21 UVB irradiation does not affect enzyme activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.21 25-hydroxyvitamin D3
-
 Homo sapiens
1.3.1.21 cyclopamine treatment of adult human epidermal keratinocytes with 0.01 mM cyclopamine results in a decrease in enzyme activity (50% of control activity at 3 h) Homo sapiens
1.3.1.21 additional information not inhibited by 1alpha,25-dihydroxyvitamin D3 and vitamin D3 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.21 cholesterol + NADP+ Homo sapiens
-
 cholesta-5,7-dien-3beta-ol + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.21 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.3.1.21 phosphoprotein
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.21 HaCaT cell
-
 Homo sapiens
-
1.3.1.21 HEKa cell human epidermal keratinocyte Homo sapiens
-
1.3.1.21 Hep-G2 cell
-
 Homo sapiens
-
1.3.1.21 hepatoma cell
-
 Homo sapiens
-
1.3.1.21 keratinocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.21 cholesterol + NADP+
-
 Homo sapiens cholesta-5,7-dien-3beta-ol + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.21 Dhcr7
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.21 NADP+
-
 Homo sapiens