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Literature summary extracted from

  • Merlino, A.; Vieites, M.; Gambino, D.; Coitino, E.L.
    Homology modeling of T. cruzi and L. major NADH-dependent fumarate reductases: ligand docking, molecular dynamics validation, and insights on their binding modes (2014), J. Mol. Graph. Model., 48, 47-59.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.6 licochalcone A
-
 Leishmania major
1.3.1.6 licochalcone A
-
 Trypanosoma cruzi
1.3.1.6 Pd(2-mercaptopyridine N-oxide)2
-
 Leishmania major
1.3.1.6 Pd(2-mercaptopyridine N-oxide)2
-
 Trypanosoma cruzi
1.3.1.6 Pt(2-mercaptopyridine N-oxide)2
-
 Leishmania major
1.3.1.6 Pt(2-mercaptopyridine N-oxide)2
-
 Trypanosoma cruzi
1.3.1.6 VO(2-mercaptopyridine N-oxide)2
-
 Leishmania major
1.3.1.6 VO(2-mercaptopyridine N-oxide)2
-
 Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.6 fumarate + NADH + H+ Trypanosoma cruzi
-
 succinate + NAD+
-
 ir
1.3.1.6 fumarate + NADH + H+ Leishmania major
-
 succinate + NAD+
-
 ir
1.3.1.6 fumarate + NADH + H+ Trypanosoma cruzi CL Brener
-
 succinate + NAD+
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.6 Leishmania major E9AEQ8
-
-
1.3.1.6 Trypanosoma cruzi Q4CYX1
-
-
1.3.1.6 Trypanosoma cruzi CL Brener Q4CYX1
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.6 fumarate + NADH + H+
-
 Trypanosoma cruzi succinate + NAD+
-
 ir
1.3.1.6 fumarate + NADH + H+
-
 Leishmania major succinate + NAD+
-
 ir
1.3.1.6 fumarate + NADH + H+
-
 Trypanosoma cruzi CL Brener succinate + NAD+
-
 ir

Synonyms

EC Number Synonyms Comment Organism
1.3.1.6 NADH-dependent fumarate reductase
-
 Trypanosoma cruzi
1.3.1.6 NADH-dependent fumarate reductase
-
 Leishmania major

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.6 NADH
-
 Trypanosoma cruzi
1.3.1.6 NADH
-
 Leishmania major

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3.1.6 0.0132
-
 licochalcone A pH and temperature not specified in the publication Leishmania major
1.3.1.6 0.0793
-
 Pd(2-mercaptopyridine N-oxide)2 pH and temperature not specified in the publication Trypanosoma cruzi
1.3.1.6 0.101
-
 Pt(2-mercaptopyridine N-oxide)2 pH and temperature not specified in the publication Trypanosoma cruzi
1.3.1.6 0.109
-
 VO(2-mercaptopyridine N-oxide)2 pH and temperature not specified in the publication Trypanosoma cruzi
1.3.1.6 0.111
-
 VO(2-mercaptopyridine N-oxide)2 pH and temperature not specified in the publication Leishmania major
1.3.1.6 0.122
-
 Pd(2-mercaptopyridine N-oxide)2 pH and temperature not specified in the publication Leishmania major
1.3.1.6 0.131
-
 Pt(2-mercaptopyridine N-oxide)2 pH and temperature not specified in the publication Leishmania major