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Literature summary extracted from

  • Belluti, F.; Perozzo, R.; Lauciello, L.; Colizzi, F.; Kostrewa, D.; Bisi, A.; Gobbi, S.; Rampa, A.; Bolognesi, M.L.; Recanatini, M.; Brun, R.; Scapozza, L.; Cavalli, A.
    Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of Plasmodium falciparum enoyl-ACP-reductase (PfFabI) (2013), J. Med. Chem., 56, 7516-7526.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.9
-
 Plasmodium falciparum

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.3.1.9 in complex with NADH and inhibitors, hanging drop vapor diffusion method Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.9 3-(4-(4-chloro-2-hydroxyphenoxy)phenyl)-7-hydroxy-2H-chromen-2-one
-
 Plasmodium falciparum
1.3.1.9 3-(4-chloro-2-hydroxyphenoxy)-4-methyl-2H-chromen-2-one
-
 Plasmodium falciparum
1.3.1.9 3-(4-chloro-2-hydroxyphenoxy)-5,7-dihydroxy-2H-chromen-2-one
-
 Plasmodium falciparum
1.3.1.9 3-(4-chloro-2-hydroxyphenoxy)-6-hydroxy-2H-chromen-2-one
-
 Plasmodium falciparum
1.3.1.9 3-(4-chloro-2-hydroxyphenoxy)-7-hydroxy-2H-chromen-2-one
-
 Plasmodium falciparum
1.3.1.9 3-(4-chloro-2-hydroxyphenoxy)-7-hydroxy-4-methyl-2H-chromen-2-one
-
 Plasmodium falciparum
1.3.1.9 6-(4-chloro-2-hydroxyphenoxy)-2H-chromen-2-one
-
 Plasmodium falciparum
1.3.1.9 6-(4-chloro-2-hydroxyphenoxy)-4-ethyl-2H-chromen-2-one
-
 Plasmodium falciparum
1.3.1.9 6-(4-chloro-2-hydroxyphenoxy)-4-methyl-2H-chromen-2-one
-
 Plasmodium falciparum
1.3.1.9 6-(4-chloro-2-hydroxyphenoxy)naphthalen-2-ol
-
 Plasmodium falciparum
1.3.1.9 7-(4-chloro-2-hydroxyphenoxy)-2H-chromen-2-one
-
 Plasmodium falciparum
1.3.1.9 7-(4-chloro-2-hydroxyphenoxy)-4-ethyl-2H-chromen-2-one
-
 Plasmodium falciparum
1.3.1.9 7-(4-chloro-2-hydroxyphenoxy)-4-methyl-2H-chromen-2-one
-
 Plasmodium falciparum
1.3.1.9 additional information not inhibited by (-)-epigallocatechin gallate, chloroquine, and podophyllotoxin Plasmodium falciparum
1.3.1.9 triclosan i.e. 5-chloro-2-(2,4-dichlorophenoxy)phenol Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.9 trans-2-enoyl-[acyl-carrier protein] + NADH + H+ Plasmodium falciparum
-
 acyl-[acyl-carrier protein] + NAD+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.9 Plasmodium falciparum C6KSZ2
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.9
-
 Plasmodium falciparum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.9 trans-2-enoyl-[acyl-carrier protein] + NADH + H+
-
 Plasmodium falciparum acyl-[acyl-carrier protein] + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.9 enoyl-ACP reductase
-
 Plasmodium falciparum
1.3.1.9 enoyl-acyl carrier protein reductase
-
 Plasmodium falciparum
1.3.1.9 ENR
-
 Plasmodium falciparum
1.3.1.9 FabI
-
 Plasmodium falciparum

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.9 NADH
-
 Plasmodium falciparum

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.3.1.9 0.00005
-
 pH and temperature not specified in the publication Plasmodium falciparum triclosan