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Literature summary extracted from

  • Struys, E.A.; Jansen, E.E.; Salomons, G.S.
    Human pyrroline-5-carboxylate reductase (PYCR1) acts on delta(1)-piperideine-6-carboxylate generating L-pipecolic acid (2014), J. Inherit. Metab. Dis., 37, 327-332.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.2 DL-pipecolic acid 65% inhibition at 10mM Homo sapiens
1.5.1.2 L-proline 94% inhibition at 10 mM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.2 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.2 piperideine-6-carboxylate + NADH + H+
-
Homo sapiens L-pipecolic acid + NAD+ L-pipecolic acid is the sole product ir
1.5.1.2 piperideine-6-carboxylate + NADPH + H+
-
Homo sapiens L-pipecolic acid + NADP+ L-pipecolic acid is the sole product ir

Synonyms

EC Number Synonyms Comment Organism
1.5.1.2 Pycr1
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.2 NADH
-
Homo sapiens
1.5.1.2 NADPH
-
Homo sapiens