EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.99.40 | 0.111 | - |
D-2-hydroxyglutarate | pH 9.5, 30°C | Saccharomyces cerevisiae | |
1.1.99.40 | 0.45 | - |
pyruvate | pH 9.5, 30°C | Saccharomyces cerevisiae |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.1.99.40 | cytosol | - |
Saccharomyces cerevisiae | 5829 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.1.99.40 | Co2+ | 0.005 mM, about 3fold stimulation | Saccharomyces cerevisiae | |
1.1.99.40 | Zn2+ | 0.005 mM, about 3fold stimulation | Saccharomyces cerevisiae |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.99.40 | Saccharomyces cerevisiae | P39976 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.1.99.40 | recombinant protein. Purified fractions show a yellow color | Saccharomyces cerevisiae |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.99.40 | 2-oxoglutarate + D-lactate | - |
Saccharomyces cerevisiae | D-2-hydroxyglutarate + pyruvate | - |
r | |
1.1.99.40 | D-2-hydroxyglutarate + oxaloacetate | - |
Saccharomyces cerevisiae | 2-oxoglutarate + malate | - |
r | |
1.1.99.40 | D-2-hydroxyglutarate + pyruvate | - |
Saccharomyces cerevisiae | 2-oxoglutarate + D-lactate | - |
r | |
1.1.99.40 | additional information | no substrate: L-lactate. The enzyme displays dehydrogenase activity with artificial acceptor dichlorophenolindophenol | Saccharomyces cerevisiae | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.99.40 | D-2-hydroxyglutarate-pyruvate transhydrogenase | - |
Saccharomyces cerevisiae |
1.1.99.40 | DLD3 | - |
Saccharomyces cerevisiae |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.99.40 | 4 | - |
D-2-hydroxyglutarate | pH 9.5, 30°C | Saccharomyces cerevisiae | |
1.1.99.40 | 4.9 | - |
pyruvate | pH 9.5, 30°C | Saccharomyces cerevisiae |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.99.40 | FAD | enzyme is a FAD-dependent transhydrogenase using pyruvate as a hydrogen acceptor | Saccharomyces cerevisiae |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.1.99.40 | physiological function | a mutant strain lacking cytosolic transhydrogenase Dld3 activity accumulates millimolar levels of D-2-hydroxyglutarate | Saccharomyces cerevisiae |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.99.40 | 12 | - |
pyruvate | pH 9.5, 30°C | Saccharomyces cerevisiae | |
1.1.99.40 | 36 | - |
D-2-hydroxyglutarate | pH 9.5, 30°C | Saccharomyces cerevisiae |