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Literature summary extracted from

  • Lu, D.; Han, C.; Wu, T.
    15-hydroxyprostaglandin dehydrogenase-derived 15-keto-prostaglandin E2 inhibits cholangiocarcinoma cell growth through interaction with peroxisome proliferator-activated receptor-gamma, SMAD2/3, and TAP63 proteins (2013), J. Biol. Chem., 288, 19484-19502.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.141 prostaglandin E2 + NAD+ Homo sapiens
-
 15-oxoprostaglandin E2 + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.141 Homo sapiens P15428
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.141 CCLP1 cell
-
 Homo sapiens
-
1.1.1.141 cholangiocarcinoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.141 prostaglandin E2 + NAD+
-
 Homo sapiens 15-oxoprostaglandin E2 + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.141 15-PGDH
-
 Homo sapiens
1.1.1.141 NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.141 NAD+
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.1.1.141 physiological function the enzyme inhibits cholangiocarcinoma cell proliferation and migration Homo sapiens