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Literature summary extracted from

  • Zhou, X.; Ma, Y.; Sugiura, R.; Kobayashi, D.; Suzuki, M.; Deng, L.; Kuno, T.
    MAP kinase kinase kinase (MAPKKK)-dependent and -independent activation of Sty1 stress MAPK in fission yeast (2010), J. Biol. Chem., 285, 32818-32823.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.25 additional information generation of DELTAwis4/wak1/wik1 single and DELTAwis4/wak1/wik1/DELTAwin1 double knockout mutants Schizosaccharomyces pombe

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.25 Mg2+ required Schizosaccharomyces pombe

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.25 ATP + Atf1 Schizosaccharomyces pombe MAPK kinase Atf1 activation ADP + phosphorylated Atf1
-
 ?
2.7.11.25 ATP + Atf1 Schizosaccharomyces pombe 972 MAPK kinase Atf1 activation ADP + phosphorylated Atf1
-
 ?
2.7.11.25 ATP + Sty1 Schizosaccharomyces pombe MAPK kinase Sty1 activation ADP + phosphorylated Sty1
-
 ?
2.7.11.25 ATP + Sty1 Schizosaccharomyces pombe 972 MAPK kinase Sty1 activation ADP + phosphorylated Sty1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.25 Schizosaccharomyces pombe O14299 genes wis4, wak1, and wik1, strain 972
-
2.7.11.25 Schizosaccharomyces pombe O74304 gene win1, strain 972
-
2.7.11.25 Schizosaccharomyces pombe 972 O14299 genes wis4, wak1, and wik1, strain 972
-
2.7.11.25 Schizosaccharomyces pombe 972 O74304 gene win1, strain 972
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.25 ATP + Atf1 MAPK kinase Atf1 activation Schizosaccharomyces pombe ADP + phosphorylated Atf1
-
 ?
2.7.11.25 ATP + Atf1 MAPK kinase Atf1 activation Schizosaccharomyces pombe 972 ADP + phosphorylated Atf1
-
 ?
2.7.11.25 ATP + Sty1 MAPK kinase Sty1 activation Schizosaccharomyces pombe ADP + phosphorylated Sty1
-
 ?
2.7.11.25 ATP + Sty1 MAPK kinase Sty1 activation Schizosaccharomyces pombe 972 ADP + phosphorylated Sty1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.25 MAP kinase kinase kinase
-
 Schizosaccharomyces pombe
2.7.11.25 MAPKKK
-
 Schizosaccharomyces pombe
2.7.11.25 Wak1
-
 Schizosaccharomyces pombe
2.7.11.25 Wik1
-
 Schizosaccharomyces pombe
2.7.11.25 Win1
-
 Schizosaccharomyces pombe
2.7.11.25 Wis4
-
 Schizosaccharomyces pombe

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.25 ATP
-
 Schizosaccharomyces pombe

General Information

EC Number General Information Comment Organism
2.7.11.25 malfunction in cadmium and low glucose medium, Atf1 activation is observed even in the absence of all four fission yeast MAPK kinase kinases (MAPKKKs), whereas in osmotic stress, Atf1 activation is abolished Schizosaccharomyces pombe
2.7.11.25 metabolism the four MAPKKKs in fission yeast are involved in MAPK activation, e.g. Atf1 or Sty1, in osmotic stress. Osmotic stress, e.g. by KCl, likely mediates the MAPK activation via MAPKKKs, whereas a cadmium or low-glucose condition activates the MAPK in a MAPKKK-independent manner. Protein-tyrosine phosphatases Pyp1 and Pyp2 are negative regulators of the Sty1 MAPK cascade Schizosaccharomyces pombe