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Literature summary extracted from

  • Constant, P.; Perez, E.; Malaga, W.; Laneelle, M.A.; Saurel, O.; Daffe, M.; Guilhot, C.
    Role of the pks15/1 gene in the biosynthesis of phenolglycolipids in the Mycobacterium tuberculosis complex. Evidence that all strains synthesize glycosylated p-hydroxybenzoic methyl esters and that strains devoid of phenolglycolipids harbor a frameshift (2002), J. Biol. Chem., 277, 38148-38158.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.261 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase] + 8 malonyl-CoA + 16 NADPH + 16 H+ Mycobacterium tuberculosis
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17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 16 NADP+ + 8 H2O
-
?
2.3.1.261 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase] + 9 malonyl-CoA + 18 NADPH + 18 H+ + holo-[4-hydroxyphenylalkanoate synthase] Mycobacterium tuberculosis
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19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 18 NADP+ + 9 H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.261 Mycobacterium tuberculosis P96284
-
-
2.3.1.261 Mycobacterium tuberculosis P96285
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-
2.3.1.261 Mycobacterium tuberculosis variant bovis
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-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.261 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase] + 8 malonyl-CoA + 16 NADPH + 16 H+
-
Mycobacterium tuberculosis 17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 16 NADP+ + 8 H2O
-
?
2.3.1.261 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase] + 9 malonyl-CoA + 18 NADPH + 18 H+ + holo-[4-hydroxyphenylalkanoate synthase]
-
Mycobacterium tuberculosis 19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 18 NADP+ + 9 H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.261 PKS1
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Mycobacterium tuberculosis variant bovis
2.3.1.261 PKS1
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Mycobacterium tuberculosis
2.3.1.261 Pks15
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Mycobacterium tuberculosis variant bovis
2.3.1.261 Pks15
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Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
2.3.1.261 physiological function a single open reading frame for pks15/1 is found in Mycobacterium bovis BCG. Disruption of the pks15/1 gene leads to the abolition of the synthesis of type-specific phenolphthiocerol glycolipid Mycobacterium tuberculosis variant bovis
2.3.1.261 physiological function polyketide synthase gene pks1 is involved in the elongation of 4hydroxybenzoic acid derivatives to form p-hydroxyphenylalkanoates, which in turn are converted, presumably by the PpsA-E synthase, to phenolphthiocerol derivatives. All the strains of Mycobacterium tuberculosis examined and deficient in the production of phenolphthiocerol derivatives are natural mutants with a frameshift mutation in pks1 Mycobacterium tuberculosis
2.3.1.261 physiological function polyketide synthase gene pks15 is involved in the elongation of 4-hydroxybenzoic acid derivatives to form p-hydroxyphenylalkanoates, which in turn are converted, presumably by the PpsA-E synthase, to phenolphthiocerol derivatives. All the strains of Mycobacterium tuberculosis examined and deficient in the production of phenolphthiocerol derivatives are natural mutants with a frameshift mutation in pks15 Mycobacterium tuberculosis