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Literature summary extracted from

  • Daugherty, M.; Polanuyer, B.; Farrell, M.; Scholle, M.; Lykidis, A.; de Crecy-Lagard, V.; Osterman, A.
    Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics (2002), J. Biol. Chem., 277, 21431-21439.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.2.51 expressed in Escherichia coli BL21 cells Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.51 ATP + (R)-4'-phosphopantothenate + L-cysteine Homo sapiens
-
 AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
 ?
6.3.2.51 CTP + (R)-4'-phosphopantothenate + L-cysteine Homo sapiens
-
 CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.51 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.2.51 Ni-NTA agarose column chromatography and Superdex 200 gel filtration Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.51 ATP + (R)-4'-phosphopantothenate + L-cysteine
-
 Homo sapiens AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
 ?
6.3.2.51 CTP + (R)-4'-phosphopantothenate + L-cysteine
-
 Homo sapiens CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.2.51 CoaB
-
 Homo sapiens
6.3.2.51 phosphopantothenoylcysteine synthetase
-
 Homo sapiens
6.3.2.51 PPCS
-
 Homo sapiens