Literature summary extracted from

Hansen, C.H.; Wittstock, U.; Olsen, C.E.; Hick, A.J.; Pickett, J.A.; Halkier, B.A.
Cytochrome p450 CYP79F1 from Arabidopsis catalyzes the conversion of dihomomethionine and trihomomethionine to the corresponding aldoximes in the biosynthesis of aliphatic glucosinolates (2001), J. Biol. Chem., 276, 11078-11085.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.14.14.42	expression in Escherichia coli	Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.14.14.42	L-dihomomethionine + 2 O2 + 2 [reduced NADPH-hemoprotein reductase]	Arabidopsis thaliana	-	omega-(methylthio)-(E)-pentanaldehyde oxime + CO2 + 3 H2O + 2 [oxidized NADPH-hemoprotein reductase]	overall reaction, product is the precursor of the major glucosinolates in leaves of Arabidopsis thaliana	?
1.14.14.42	L-trihomomethionine + 2 O2 + 2 [reduced NADPH-hemoprotein reductase]	Arabidopsis thaliana	-	omega-(methylthio)-(E)-hexanaldehyde oxime + CO2 + 3 H2O + 2 [oxidized NADPH-hemoprotein reductase]	overall reaction	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.14.42	Arabidopsis thaliana	Q949U1	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.14.42	L-dihomomethionine + 2 O2 + 2 [reduced NADPH-hemoprotein reductase]	-	Arabidopsis thaliana	omega-(methylthio)-(E)-pentanaldehyde oxime + CO2 + 3 H2O + 2 [oxidized NADPH-hemoprotein reductase]	overall reaction, product is the precursor of the major glucosinolates in leaves of Arabidopsis thaliana	?
1.14.14.42	L-trihomomethionine + 2 O2 + 2 [reduced NADPH-hemoprotein reductase]	-	Arabidopsis thaliana	omega-(methylthio)-(E)-hexanaldehyde oxime + CO2 + 3 H2O + 2 [oxidized NADPH-hemoprotein reductase]	overall reaction	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.14.14.42	CYP79F1	-	Arabidopsis thaliana
1.14.14.42	dihomomethionine N-hydroxylase	-	Arabidopsis thaliana

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.14.14.42	cytochrome P450	-	Arabidopsis thaliana

General Information

EC Number	General Information	Comment	Organism
1.14.14.42	physiological function	transgenic Arabidopsis thaliana with cosuppression of CYP79F1 have a reduced content of aliphatic glucosinolates and a highly increased level of dihomomethionine and trihomomethionine. The transgenic plants have a morphological phenotype showing loss of apical dominance and formation of multiple axillary shoots	Arabidopsis thaliana

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Release 2023.1 (January 2023)