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Literature summary extracted from

  • Schaeffer, M.L.; Khoo, K.H.; Besra, G.S.; Chatterjee, D.; Brennan, P.J.; Belisle, J.T.; Inamine, J.M.
    The pimB gene of Mycobacterium tuberculosis encodes a mannosyltransferase involved in lipoarabinomannan biosynthesis (1999), J. Biol. Chem., 274, 31625-31631.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.346 expression in Escherichia coli and Mycoacterium smegmatis Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.346 D-mannosamine does not bind directly or efficiently to the active site of the enzyme, but interferes indirectly with the enzyme’s access to GDP-Man Mycobacterium tuberculosis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.346 membrane
-
 Mycobacterium tuberculosis 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.1.346 41200
-
 x * 41200, calculated Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.346 Mycobacterium tuberculosis P9WMY5
-
-
2.4.1.346 Mycobacterium tuberculosis H37Rv P9WMY5
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.346 GDP-alpha-D-mannose + 2-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol
-
 Mycobacterium tuberculosis GDP + 2,6-di-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol
-
 ?
2.4.1.346 GDP-alpha-D-mannose + 2-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol
-
 Mycobacterium tuberculosis H37Rv GDP + 2,6-di-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.1.346 ? x * 41200, calculated Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
2.4.1.346 MgtA
-
 Mycobacterium tuberculosis
2.4.1.346 PimB
-
 Mycobacterium tuberculosis