EC Number | Cloned (Comment) | Organism |
---|---|---|
1.1.1.27 | gene ldh, real-time quantitative reverse transcription-PCR enzyme expression analysis | Streptococcus mutans serotype c |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.27 | (S)-lactate + NAD+ | Streptococcus mutans serotype c | - |
pyruvate + NADH + H+ | - |
r | |
1.1.1.27 | (S)-lactate + NAD+ | Streptococcus mutans serotype c UA159 | - |
pyruvate + NADH + H+ | - |
r | |
1.1.1.27 | pyruvate + NADH + H+ | Streptococcus mutans serotype c | - |
(S)-lactate + NAD+ | - |
r | |
1.1.1.27 | pyruvate + NADH + H+ | Streptococcus mutans serotype c UA159 | - |
(S)-lactate + NAD+ | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.27 | Streptococcus mutans serotype c | P26283 | - |
- |
1.1.1.27 | Streptococcus mutans serotype c UA159 | P26283 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.27 | cell culture | steady-state growth at pH 7 and pH 5 | Streptococcus mutans serotype c | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.27 | (S)-lactate + NAD+ | - |
Streptococcus mutans serotype c | pyruvate + NADH + H+ | - |
r | |
1.1.1.27 | (S)-lactate + NAD+ | - |
Streptococcus mutans serotype c UA159 | pyruvate + NADH + H+ | - |
r | |
1.1.1.27 | pyruvate + NADH + H+ | - |
Streptococcus mutans serotype c | (S)-lactate + NAD+ | - |
r | |
1.1.1.27 | pyruvate + NADH + H+ | - |
Streptococcus mutans serotype c UA159 | (S)-lactate + NAD+ | - |
r |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.27 | L-LDH | - |
Streptococcus mutans serotype c |
1.1.1.27 | lactate dehydrogenase | - |
Streptococcus mutans serotype c |
1.1.1.27 | LDH | - |
Streptococcus mutans serotype c |
1.1.1.27 | SMU.1115 | - |
Streptococcus mutans serotype c |
1.1.1.27 | SMU_1115 | - |
Streptococcus mutans serotype c |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.27 | NAD+ | - |
Streptococcus mutans serotype c | |
1.1.1.27 | NADH | - |
Streptococcus mutans serotype c |
EC Number | Organism | Comment | Expression |
---|---|---|---|
1.1.1.27 | Streptococcus mutans serotype c | deletion of water-forming NADH oxidase NOX in Streptococcus mutans leads to significantly elevated lactate dehydrogenase activity and gene ldh transcription in the DELTAnox strain, which is mediated in part by the redox-sensing regulator Rex. Rex activation of ldh transcription | up |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.1.1.27 | malfunction | loss of water-forming NADH oxidase NOX activity in Streptococcus mutans leads to Rex-mediated overcompensation in NAD+ regeneration by lactate dehydrogenase. The altered transcriptome and metabolome of the DELTAnox strain are sufficient to impair its ability to compete with commensal peroxigenic oral streptococci during growth under aerobic conditions, phenotype, overview | Streptococcus mutans serotype c |