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Literature summary extracted from

  • Baker, J.L.; Derr, A.M.; Faustoferri, R.C.; Quivey, R.G.
    Loss of NADH oxidase activity in Streptococcus mutans leads to Rex-mediated overcompensation in NAD+ regeneration by lactate dehydrogenase (2015), J. Bacteriol., 197, 3645-3657.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.27 gene ldh, real-time quantitative reverse transcription-PCR enzyme expression analysis Streptococcus mutans serotype c

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.27 (S)-lactate + NAD+ Streptococcus mutans serotype c
-
pyruvate + NADH + H+
-
r
1.1.1.27 (S)-lactate + NAD+ Streptococcus mutans serotype c UA159
-
pyruvate + NADH + H+
-
r
1.1.1.27 pyruvate + NADH + H+ Streptococcus mutans serotype c
-
(S)-lactate + NAD+
-
r
1.1.1.27 pyruvate + NADH + H+ Streptococcus mutans serotype c UA159
-
(S)-lactate + NAD+
-
r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.27 Streptococcus mutans serotype c P26283
-
-
1.1.1.27 Streptococcus mutans serotype c UA159 P26283
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.27 cell culture steady-state growth at pH 7 and pH 5 Streptococcus mutans serotype c
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.27 (S)-lactate + NAD+
-
Streptococcus mutans serotype c pyruvate + NADH + H+
-
r
1.1.1.27 (S)-lactate + NAD+
-
Streptococcus mutans serotype c UA159 pyruvate + NADH + H+
-
r
1.1.1.27 pyruvate + NADH + H+
-
Streptococcus mutans serotype c (S)-lactate + NAD+
-
r
1.1.1.27 pyruvate + NADH + H+
-
Streptococcus mutans serotype c UA159 (S)-lactate + NAD+
-
r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.27 L-LDH
-
Streptococcus mutans serotype c
1.1.1.27 lactate dehydrogenase
-
Streptococcus mutans serotype c
1.1.1.27 LDH
-
Streptococcus mutans serotype c
1.1.1.27 SMU.1115
-
Streptococcus mutans serotype c
1.1.1.27 SMU_1115
-
Streptococcus mutans serotype c

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.27 NAD+
-
Streptococcus mutans serotype c
1.1.1.27 NADH
-
Streptococcus mutans serotype c

Expression

EC Number Organism Comment Expression
1.1.1.27 Streptococcus mutans serotype c deletion of water-forming NADH oxidase NOX in Streptococcus mutans leads to significantly elevated lactate dehydrogenase activity and gene ldh transcription in the DELTAnox strain, which is mediated in part by the redox-sensing regulator Rex. Rex activation of ldh transcription up

General Information

EC Number General Information Comment Organism
1.1.1.27 malfunction loss of water-forming NADH oxidase NOX activity in Streptococcus mutans leads to Rex-mediated overcompensation in NAD+ regeneration by lactate dehydrogenase. The altered transcriptome and metabolome of the DELTAnox strain are sufficient to impair its ability to compete with commensal peroxigenic oral streptococci during growth under aerobic conditions, phenotype, overview Streptococcus mutans serotype c