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Literature summary extracted from

  • Sirakova, T.; Fitzmaurice, A.; Kolattukudy, P.
    Regulation of expression of mas and fadD28, two genes involved in production of dimycocerosyl phthiocerol, a virulence factor of Mycobacterium tuberculosis (2002), J. Bacteriol., 184, 6796-6802.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.2.1.49 expressed in Escherichia coli and Mycobacterium smegmatis Mycobacterium tuberculosis variant bovis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.49 ATP + a long-chain fatty acid + holo-[mycocerosate synthase] Mycobacterium tuberculosis
-
 AMP + diphosphate + a long-chain acyl-[mycocerosate synthase]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.49 Mycobacterium tuberculosis
-
-
-
6.2.1.49 Mycobacterium tuberculosis variant bovis Q02278
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.49 ATP + a long-chain fatty acid + holo-[mycocerosate synthase]
-
 Mycobacterium tuberculosis AMP + diphosphate + a long-chain acyl-[mycocerosate synthase]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.2.1.49 fadD28
-
 Mycobacterium tuberculosis
6.2.1.49 fadD28
-
 Mycobacterium tuberculosis variant bovis

General Information

EC Number General Information Comment Organism
6.2.1.49 physiological function the enzyme is involved in the synthesis of the virulence factor dimycocerosyl phthiocerol Mycobacterium tuberculosis variant bovis