BRENDA - Enzyme Database

Mitochondrial NADP+-dependent isocitrate dehydrogenase deficiency exacerbates mitochondrial and cell damage after kidney ischemia-reperfusion injury

Han, S.J.; Jang, H.S.; Noh, M.R.; Kim, J.; Kong, M.J.; Kim, J.I.; Park, J.W.; Park, K.M.; J. Am. Soc. Nephrol. 28, 1200-1215 (2017)

Data extracted from this reference:

Engineering
EC Number
Amino acid exchange
Commentary
Organism
1.1.1.42
additional information
Idh2 gene deletion, generation of Idh2-/- mice, phenotype,overview
Mus musculus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.42
additional information
ischemia-reperfusion reduces IDH2 expression and activity in both Idh2+/+ and Idh2-/- kidneys
Mus musculus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.1.1.42
mitochondrion
-
Mus musculus
5739
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.42
isocitrate + NADP+
Mus musculus
-
2-oxoglutarate + NADPH + H+
-
-
r
1.1.1.42
isocitrate + NADP+
Mus musculus C57BL/6
-
2-oxoglutarate + NADPH + H+
-
-
r
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.42
Mus musculus
P54071
-
-
1.1.1.42
Mus musculus C57BL/6
P54071
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.42
kidney
-
Mus musculus
-
1.1.1.42
renal proximal tubule cell
-
Mus musculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.42
isocitrate + NADP+
-
740583
Mus musculus
2-oxoglutarate + NADPH + H+
-
-
-
r
1.1.1.42
isocitrate + NADP+
-
740583
Mus musculus C57BL/6
2-oxoglutarate + NADPH + H+
-
-
-
r
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.42
NADP+
-
Mus musculus
1.1.1.42
NADPH
-
Mus musculus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.42
NADP+
-
Mus musculus
1.1.1.42
NADPH
-
Mus musculus
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
1.1.1.42
additional information
Idh2 gene deletion, generation of Idh2-/- mice, phenotype,overview
Mus musculus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.42
additional information
ischemia-reperfusion reduces IDH2 expression and activity in both Idh2+/+ and Idh2-/- kidneys
Mus musculus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.1.1.42
mitochondrion
-
Mus musculus
5739
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.42
isocitrate + NADP+
Mus musculus
-
2-oxoglutarate + NADPH + H+
-
-
r
1.1.1.42
isocitrate + NADP+
Mus musculus C57BL/6
-
2-oxoglutarate + NADPH + H+
-
-
r
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.42
kidney
-
Mus musculus
-
1.1.1.42
renal proximal tubule cell
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.42
isocitrate + NADP+
-
740583
Mus musculus
2-oxoglutarate + NADPH + H+
-
-
-
r
1.1.1.42
isocitrate + NADP+
-
740583
Mus musculus C57BL/6
2-oxoglutarate + NADPH + H+
-
-
-
r
Expression
EC Number
Organism
Commentary
Expression
1.1.1.42
Mus musculus
ischemia-reperfusion reduces IDH2 expression and activity in both Idh2+/+ and Idh2-/- kidneys. IDH1 expression decreases 1 day after ischemia and then returns to around normal level by 16 days after ischemia
down
General Information
EC Number
General Information
Commentary
Organism
1.1.1.42
malfunction
mitochondrial NADP+-dependent isocitrate dehydrogenase deficiency exacerbates mitochondrial and cell damage after kidney ischemia-reperfusion injury, Idh2 gene deletion exacerbates ROS production and oxidative stress after ischemia-reperfusion, and causes I/R-induced mitochondrial dysfunction and morphologic fragmentation, resulting in severe apoptosis in kidney tubule cells, it impairs reduction of NADP+ and GSSG within mitochondria
Mus musculus
1.1.1.42
physiological function
mitochondrial NADP+-dependent isocitrate dehydrogenase (IDH2) catalyzes the oxidative decarboxylation of isocitrate to 2-oxooglutarate, synthesizing NADPH, which is essential for mitochondrial redox balance
Mus musculus
General Information (protein specific)
EC Number
General Information
Commentary
Organism
1.1.1.42
malfunction
mitochondrial NADP+-dependent isocitrate dehydrogenase deficiency exacerbates mitochondrial and cell damage after kidney ischemia-reperfusion injury, Idh2 gene deletion exacerbates ROS production and oxidative stress after ischemia-reperfusion, and causes I/R-induced mitochondrial dysfunction and morphologic fragmentation, resulting in severe apoptosis in kidney tubule cells, it impairs reduction of NADP+ and GSSG within mitochondria
Mus musculus
1.1.1.42
physiological function
mitochondrial NADP+-dependent isocitrate dehydrogenase (IDH2) catalyzes the oxidative decarboxylation of isocitrate to 2-oxooglutarate, synthesizing NADPH, which is essential for mitochondrial redox balance
Mus musculus
Expression (protein specific)
EC Number
Organism
Commentary
Expression
1.1.1.42
Mus musculus
ischemia-reperfusion reduces IDH2 expression and activity in both Idh2+/+ and Idh2-/- kidneys. IDH1 expression decreases 1 day after ischemia and then returns to around normal level by 16 days after ischemia
down