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Literature summary extracted from

  • Patrone, J.D.; Yao, J.; Scott, N.E.; Dotson, G.D.
    Selective inhibitors of bacterial phosphopantothenoylcysteine synthetase (2009), J. Am. Chem. Soc., 131, 16340-16341.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.51 5'-O-[hydroxy(3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]propoxy)phosphoryl]cytidine
-
 Enterococcus faecalis
6.3.2.51 5'-O-[hydroxy(3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]propoxy)phosphoryl]cytidine
-
 Escherichia coli
6.3.2.51 5'-O-[hydroxy(3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]propoxy)phosphoryl]cytidine
-
 Homo sapiens
6.3.2.51 5'-O-[hydroxy(3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]propoxy)phosphoryl]cytidine
-
 Streptococcus pneumoniae
6.3.2.51 5'-O-[hydroxy(3-[[(4R)-2-hydroxy-5,5-dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinane-4-carbonyl]amino]propoxy)phosphoryl]cytidine
-
 Enterococcus faecalis
6.3.2.51 5'-O-[hydroxy(3-[[(4R)-2-hydroxy-5,5-dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinane-4-carbonyl]amino]propoxy)phosphoryl]cytidine
-
 Escherichia coli
6.3.2.51 5'-O-[hydroxy(3-[[(4R)-2-hydroxy-5,5-dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinane-4-carbonyl]amino]propoxy)phosphoryl]cytidine
-
 Homo sapiens
6.3.2.51 5'-O-[hydroxy(3-[[(4R)-2-hydroxy-5,5-dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinane-4-carbonyl]amino]propoxy)phosphoryl]cytidine
-
 Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.51 ATP + (R)-4'-phosphopantothenate + L-cysteine Escherichia coli
-
 AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
 ?
6.3.2.51 ATP + (R)-4'-phosphopantothenate + L-cysteine Homo sapiens
-
 AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
 ?
6.3.2.51 ATP + (R)-4'-phosphopantothenate + L-cysteine Enterococcus faecalis
-
 AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
 ?
6.3.2.51 ATP + (R)-4'-phosphopantothenate + L-cysteine Streptococcus pneumoniae
-
 AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.51 Enterococcus faecalis
-
-
-
6.3.2.51 Escherichia coli
-
-
-
6.3.2.51 Homo sapiens
-
-
-
6.3.2.51 Streptococcus pneumoniae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.51 ATP + (R)-4'-phosphopantothenate + L-cysteine
-
 Escherichia coli AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
 ?
6.3.2.51 ATP + (R)-4'-phosphopantothenate + L-cysteine
-
 Homo sapiens AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
 ?
6.3.2.51 ATP + (R)-4'-phosphopantothenate + L-cysteine
-
 Enterococcus faecalis AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
 ?
6.3.2.51 ATP + (R)-4'-phosphopantothenate + L-cysteine
-
 Streptococcus pneumoniae AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
 ?
6.3.2.51 CTP + (R)-4'-phosphopantothenate + L-cysteine
-
 Escherichia coli CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
 ?
6.3.2.51 CTP + (R)-4'-phosphopantothenate + L-cysteine
-
 Homo sapiens CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
 ?
6.3.2.51 CTP + (R)-4'-phosphopantothenate + L-cysteine
-
 Enterococcus faecalis CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
 ?
6.3.2.51 CTP + (R)-4'-phosphopantothenate + L-cysteine
-
 Streptococcus pneumoniae CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.2.51 CoaB
-
 Escherichia coli
6.3.2.51 CoaB
-
 Homo sapiens
6.3.2.51 CoaB
-
 Enterococcus faecalis
6.3.2.51 CoaB
-
 Streptococcus pneumoniae
6.3.2.51 phosphopantothenoylcysteine synthetase
-
 Escherichia coli
6.3.2.51 phosphopantothenoylcysteine synthetase
-
 Homo sapiens
6.3.2.51 phosphopantothenoylcysteine synthetase
-
 Enterococcus faecalis
6.3.2.51 phosphopantothenoylcysteine synthetase
-
 Streptococcus pneumoniae
6.3.2.51 PPCS
-
 Escherichia coli
6.3.2.51 PPCS
-
 Homo sapiens
6.3.2.51 PPCS
-
 Enterococcus faecalis
6.3.2.51 PPCS
-
 Streptococcus pneumoniae

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
6.3.2.51 0.00001
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 5'-O-[hydroxy(3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]propoxy)phosphoryl]cytidine
6.3.2.51 0.000065
-
 pH and temperature not specified in the publication Enterococcus faecalis 5'-O-[hydroxy(3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]propoxy)phosphoryl]cytidine
6.3.2.51 0.000068
-
 pH and temperature not specified in the publication Escherichia coli 5'-O-[hydroxy(3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]propoxy)phosphoryl]cytidine
6.3.2.51 0.003
-
 pH and temperature not specified in the publication Escherichia coli 5'-O-[hydroxy(3-[[(4R)-2-hydroxy-5,5-dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinane-4-carbonyl]amino]propoxy)phosphoryl]cytidine
6.3.2.51 0.01
-
 pH and temperature not specified in the publication Homo sapiens 5'-O-[hydroxy(3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]propoxy)phosphoryl]cytidine
6.3.2.51 0.013
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 5'-O-[hydroxy(3-[[(4R)-2-hydroxy-5,5-dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinane-4-carbonyl]amino]propoxy)phosphoryl]cytidine
6.3.2.51 0.018
-
 pH and temperature not specified in the publication Enterococcus faecalis 5'-O-[hydroxy(3-[[(4R)-2-hydroxy-5,5-dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinane-4-carbonyl]amino]propoxy)phosphoryl]cytidine
6.3.2.51 2.7
-
 pH and temperature not specified in the publication Homo sapiens 5'-O-[hydroxy(3-[[(4R)-2-hydroxy-5,5-dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinane-4-carbonyl]amino]propoxy)phosphoryl]cytidine