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Literature summary extracted from

  • Castro-Sanchez, L.; Agra, N.; Llorente Izquierdo, C.; Motino, O.; Casado, M.; Bosca, L.; Martin-Sanz, P.
    Regulation of 15-hydroxyprostaglandin dehydrogenase expression in hepatocellular carcinoma (2013), Int. J. Biochem. Cell Biol., 45, 2501-2511.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.141 25000
-
 x * 25000, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.141 Homo sapiens P15428
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.141 Chang liver cell
-
 Homo sapiens
-
1.1.1.141 HEP-3B cell
-
 Homo sapiens
-
1.1.1.141 Hep-G2 cell
-
 Homo sapiens
-
1.1.1.141 hepatocellular carcinoma cell
-
 Homo sapiens
-
1.1.1.141 HuH-6 cell
-
 Homo sapiens
-
1.1.1.141 Huh-7 cell
-
 Homo sapiens
-
1.1.1.141 WRL-68 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.141 prostaglandin E2 + NAD+
-
 Homo sapiens 15-oxoprostaglandin E2 + NADH + H+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.141 ? x * 25000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.1.1.141 15-PGDH
-
 Homo sapiens
1.1.1.141 NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
-
 Homo sapiens
1.1.1.141 nicotinamide adenine dinucleotide-dependent 15-hydroxyprostaglandin dehydrogenase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.141 NAD+
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.1.1.141 Homo sapiens the enzyme is downregulated in human hepatoma cells with a high cyclooxygenase-2 expression down