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Literature summary extracted from

  • Aceves-Ramos, A.; de la Torre, P.; Hinojosa, L.; Ponce, A.; Garcํa-Villegas, R.; Laclette, J.P.; Bobes, R.J.; Romano, M.C.
    Cloning, characterization and functional expression of Taenia solium 17 beta-hydroxysteroid dehydrogenase (2014), Gen. Comp. Endocrinol., 203, 186-192.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.51 cloning by in silico blast searches in the Taenia solium genome database and RT-PCR, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, transient recombinant expression in HEK-293T cells Taenia solium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.51 additional information Taenia solium poor activity with estrone ?
-
 ?
1.1.1.51 testosterone + NADP+ Taenia solium
-
 androstenedione + NADPH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.51 Taenia solium
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.51 cyst
-
 Taenia solium
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.51 additional information poor activity with estrone Taenia solium ?
-
 ?
1.1.1.51 testosterone + NADP+
-
 Taenia solium androstenedione + NADPH + H+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.51 17beta-HSD
-
 Taenia solium
1.1.1.51 17beta-hydroxysteroid dehydrogenases
-
 Taenia solium

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.51 NADP+
-
 Taenia solium
1.1.1.51 NADPH
-
 Taenia solium

General Information

EC Number General Information Comment Organism
1.1.1.51 evolution enzyme Tsol-17betaHSD belongs to the short-chain dehydrogenase/reductase (SDR) protein superfamily, it shares motifs and activity with the type 3 enzyme of some other species Taenia solium
1.1.1.51 physiological function 17beta-hydroxysteroid dehydrogenases (17beta-HSD) are key enzymes involved in the formation (reduction) and inactivation (oxidation) of sex steroids. Taenia solium cysticerci are able to synthesize sex steroid hormones in vitro when precursors are provided in the culture medium Taenia solium