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Literature summary extracted from

  • Gibbs, P.E.; Miralem, T.; Maines, M.D.
    Biliverdin reductase: a target for cancer therapy? (2015), Front. Pharmacol., 6, 119.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.24 cytosol
-
 Homo sapiens 5829
-
1.3.1.24 nucleus
-
 Homo sapiens 5634
-
1.3.1.24 plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.24 biliverdin + NADH + H+ Homo sapiens
-
 bilirubin + NAD+
-
 r
1.3.1.24 biliverdin + NADPH + H+ Homo sapiens
-
 bilirubin + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.24 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.24 kidney
-
 Homo sapiens
-
1.3.1.24 lymphocyte
-
 Homo sapiens
-
1.3.1.24 macrophage
-
 Homo sapiens
-
1.3.1.24 monocyte
-
 Homo sapiens
-
1.3.1.24 renal tumor cell
-
 Homo sapiens
-
1.3.1.24 T-cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.24 biliverdin + NADH + H+
-
 Homo sapiens bilirubin + NAD+
-
 r
1.3.1.24 biliverdin + NADPH + H+
-
 Homo sapiens bilirubin + NADP+
-
 r
1.3.1.24 additional information protein kinase Cdelta is activated by the enzyme. Protein kinase Cdelta is not a substrate for the enzyme in vitro Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.24 BVR
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.24 NADH
-
 Homo sapiens
1.3.1.24 NADPH
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.3.1.24 Homo sapiens the transcript and protein levels are increased in human tumors and the infiltrating T-cells, monocytes and circulating lymphocytes, as well as the circulating and infiltrating macrophages up

General Information

EC Number General Information Comment Organism
1.3.1.24 physiological function the cytoprotective role of the enzyme may be permissive for cancer/tumor growth. The enzyme plays a role in transporting kinases to the membrane and nucleus and can also transport heme within the cell. The enzyme suppresses the activity of Goodpasture antigen-binding protein and hence limits the exposure of the epitope of Goodpasture antigen, thus limiting autoimmunity Homo sapiens