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Literature summary extracted from

  • Pitaluga, A.N.; Moreira, M.E.; Traub-Csekoe, Y.M.
    A putative role for inosine 5 monophosphate dehydrogenase (IMPDH) in Leishmania amazonensis programmed cell death (2015), Exp. Parasitol., 149, 32-38.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.205 additional information no inhibition by tiazofurin and benzamide Leishmania amazonensis
1.1.1.205 Mycophenolic acid
-
Leishmania amazonensis
1.1.1.205 ribavirin
-
Leishmania amazonensis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.205 IMP + NAD+ + H2O Leishmania amazonensis
-
XMP + NADH + H+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.205 Leishmania amazonensis Q2TUW2
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.205 promastigote
-
Leishmania amazonensis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.205 IMP + NAD+ + H2O
-
Leishmania amazonensis XMP + NADH + H+
-
?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.205 IMPDH
-
Leishmania amazonensis
1.1.1.205 inosine 5' monophosphate dehydrogenase
-
Leishmania amazonensis

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.205 NAD+
-
Leishmania amazonensis

Expression

EC Number Organism Comment Expression
1.1.1.205 Leishmania amazonensis downregulation of impdh expression under heat shock treatment down

General Information

EC Number General Information Comment Organism
1.1.1.205 malfunction IMPDH inhibitors ribavirin and mycophenolic acid prevents cell growth and generates an apoptosis-like phenotype in sub-populations of L.eishmania amazonensis promastigotes. A subpopulation of parasites undergoes apoptosislike cell death in the nutrient poor environment of the vector gut Leishmania amazonensis
1.1.1.205 metabolism IMPDH is a key enzyme in the purine nucleotide pathway Leishmania amazonensis
1.1.1.205 physiological function a small percentage of Leishmania amazonensis undergoes programmed cell death (PCD) under heat shock, imitating host infection reaction, involving the enzyme IMPDH of the purine metabolism. Enzyme IMPDH is a key enzyme in the purine nucleotide pathway, and is related to cell growth and apoptosis Leishmania amazonensis