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Literature summary extracted from

  • Skodova, I.; Verner, Z.; Bringaud, F.; Fabian, P.; Lukes, J.; Horvatha, A.
    Characterization of two mitochondrial flavin adenine dinucleotide-dependent glycerol-3-phosphate dehydrogenases in Trypanosoma brucei (2013), Eukaryot. Cell, 12, 1664-1673.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.5.3 mitochondrion
-
Trypanosoma brucei 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.5.3 sn-glycerol 3-phosphate + a quinone Trypanosoma brucei
-
glycerone phosphate + a quinol
-
?
1.1.5.3 sn-glycerol 3-phosphate + a quinone Trypanosoma brucei 29-13
-
glycerone phosphate + a quinol
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.5.3 Trypanosoma brucei
-
-
-
1.1.5.3 Trypanosoma brucei 29-13
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.5.3 DL-glycerol 3-phosphate + oxidized 2,6-dichlorophenolindophenol
-
Trypanosoma brucei dihydroxyacetone phosphate + reduced 2,6-dichlorophenolindophenol
-
?
1.1.5.3 DL-glycerol 3-phosphate + oxidized 2,6-dichlorophenolindophenol
-
Trypanosoma brucei 29-13 dihydroxyacetone phosphate + reduced 2,6-dichlorophenolindophenol
-
?
1.1.5.3 sn-glycerol 3-phosphate + a quinone
-
Trypanosoma brucei glycerone phosphate + a quinol
-
?
1.1.5.3 sn-glycerol 3-phosphate + a quinone
-
Trypanosoma brucei 29-13 glycerone phosphate + a quinol
-
?

Synonyms

EC Number Synonyms Comment Organism
1.1.5.3 FAD-G3PDH
-
Trypanosoma brucei
1.1.5.3 flavin adenine dinucleotide-dependent glycerol-3-phosphate dehydrogenase
-
Trypanosoma brucei
1.1.5.3 mtG3PDH isoform Trypanosoma brucei
1.1.5.3 putG3PDH isoform Trypanosoma brucei

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.5.3 FAD
-
Trypanosoma brucei

General Information

EC Number General Information Comment Organism
1.1.5.3 physiological function isoform mtG3PDH is essential for the bloodstream stage of Trypanosoma brucei, while in the procyclic stage the enzyme is dispensable Trypanosoma brucei