Literature summary extracted from

Morelli, V.; Polledri, E.; Mercadante, R.; Zhukouskaya, V.; Palmieri, S.; Beck-Peccoz, P.; Spada, A.; Fustinoni, S.; Chiodini, I.
The activity of 11beta-hydroxysteroid dehydrogenase type 2 enzyme and cortisol secretion in patients with adrenal incidentalomas (2016), Endocrine, 53, 809-815.

Application

EC Number	Application	Comment	Organism
1.1.1.146	medicine	the enzyme activity is inversely associated with urinary cortisol/cortisone levels and it is not associated with the subclinical hypercortisolism complications	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.1.1.146	cortisol + NADP+	Homo sapiens	-	cortisone + NADPH + H+	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.146	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.146	cortisol + NADP+	-	Homo sapiens	cortisone + NADPH + H+	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.1.1.146	11beta-hydroxysteroid dehydrogenase type 2	-	Homo sapiens
1.1.1.146	Hsd11B2	-	Homo sapiens

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.1.1.146	NADP+	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)