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Literature summary extracted from

  • Ferguson, D.C.; Cheng, Q.; Blanco, J.G.
    Characterization of the canine snthracycline-metabolizing enzyme carbonyl reductase 1 (cbr1) and the functional isoform cbr1 V218 (2015), Drug Metab. Dispos., 43, 922-927.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.184 expression in Escherichia coli Canis lupus familiaris

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.184 D218V single nucleotide polymorphism Canis lupus familiaris

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.184 rutin competitive Canis lupus familiaris

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.184 0.104
-
 daunorubicin mutant D218V, pH 7.4, 37°C Canis lupus familiaris
1.1.1.184 0.118
-
 menadione mutant D218V, pH 7.4, 37°C Canis lupus familiaris
1.1.1.184 0.188
-
 daunorubicin wild-type, pH 7.4, 37°C Canis lupus familiaris
1.1.1.184 0.527
-
 menadione wild-type, pH 7.4, 37°C Canis lupus familiaris

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.184 32800
-
-
 Canis lupus familiaris

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.184 Canis lupus familiaris J9P7P2
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.184 liver
-
 Canis lupus familiaris
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.184 daunorubicin + NADPH + H+
-
 Canis lupus familiaris daunorubicinol + NADP+
-
 ?
1.1.1.184 menadione + NADPH + H+
-
 Canis lupus familiaris ? + NADP+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.184 ? x * 32800, SDS-PAGE, recombinant His-tagged protein Canis lupus familiaris

Synonyms

EC Number Synonyms Comment Organism
1.1.1.184 CBR1
-
 Canis lupus familiaris
1.1.1.184 LOC610164 locus name Canis lupus familiaris

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.184 1.12
-
 menadione mutant D218V, pH 7.4, 37°C Canis lupus familiaris
1.1.1.184 1.12
-
 daunorubicin mutant D218V, pH 7.4, 37°C Canis lupus familiaris
1.1.1.184 3.52
-
 daunorubicin wild-type, pH 7.4, 37°C Canis lupus familiaris
1.1.1.184 8.48
-
 menadione wild-type, pH 7.4, 37°C Canis lupus familiaris

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.184 0.0014
-
 mutant D218V, pH 7.4, 37°C Canis lupus familiaris rutin
1.1.1.184 0.0018
-
 wild-type, pH 7.4, 37°C Canis lupus familiaris rutin