Literature summary extracted from
Lee, E.S.; Rasmussen, C.A.; Filla, M.S.; Slauson, S.R.; Kolb, A.W.; Peters, D.M.; Kaufman, P.L.; Gabelt, B.T.; Brandt, C.R.
Prospects for lentiviral vector mediated prostaglandin F synthase gene delivery in monkey eyes in vivo (2014), Curr. Eye Res., 39, 859-870.
Application
EC Number |
Application |
Comment |
Organism |
---|
1.1.1.188 |
medicine |
lentiviral vector-mediated delivery of the prostaglandin F synthase (PGFS) gene resultes in long-term reduction of intraocular pressure and may eliminate off-target tissue effects and the need for daily topical PGF2alpha self-administration |
Bos taurus |
Cloned(Commentary)
EC Number |
Cloned (Comment) |
Organism |
---|
1.1.1.188 |
expression of myc-tagged GFP-PGFS in non-human primate eyes via FIV vector leading to a significant reduction of intraocular pressure, IOP, the GFP-tag can still be detected after 48-52 weeks, the decrease in IOP lasted for 5 months, method evaluation |
Bos taurus |
Protein Variants
EC Number |
Protein Variants |
Comment |
Organism |
---|
1.1.1.188 |
additional information |
lentiviral vector-mediated delivery of the prostaglandin F synthase (PGFS) gene to the eye. Expression of myc-tagged GFP-PGFS in non-human primate eyes via FIV vector leads to a significant reduction of intraocular pressure, IOP, the GFP-tag can still be detected after 48-52 weeks, the decrease in IOP lasts for 5 months. The IOP decrease is not as much as seen with topical prostaglandin therapy in monkey eyes, method evaluation. In human eye a single injection of lentiviral vectors into either the anterior or posterior chambers can induce a transient uveitis. Following transcorneal injection of vector into the living monkey eyes, biomicroscopic examination initially reveal cells and flare in the anterior chamber and some corneal haze that is largely resolved by 3 weeks post injection. This is not due to bacterial endotoxin contamination of the vector preparations and is likely the result of activation of innate viral sensors in the eye |
Bos taurus |
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
1.1.1.188 |
Bos taurus |
- |
- |
- |
Source Tissue
EC Number |
Source Tissue |
Comment |
Organism |
Textmining |
---|
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
1.1.1.188 |
PGFS |
- |
Bos taurus |
1.1.1.188 |
prostaglandin F synthase |
- |
Bos taurus |
General Information
EC Number |
General Information |
Comment |
Organism |
---|
1.1.1.188 |
physiological function |
lentiviral vector-mediated delivery of the prostaglandin F synthase (PGFS) gene resultes in long-term reduction of intraocular pressure and may eliminate off-target tissue effects and the need for daily topical PGF2alpha self-administration |
Bos taurus |