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Literature summary extracted from

  • Brown, S.; Zhang, Y.; Walker, S.
    a revised pathway proposed for Staphylococcus aureus wall teichoic acid biosynthesis based on in vitro reconstitution of the intracellular steps (2008), Chem. Biol., 15, 12-21.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.8.45 expression in Escherichia coli Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.44 CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol Staphylococcus aureus
-
 CDP + 4-O-((2R)-1-glycerophospho)-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 ?
2.7.8.44 CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol Staphylococcus aureus NCTC 8325
-
 CDP + 4-O-((2R)-1-glycerophospho)-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.44 Staphylococcus aureus Q2G2X4
-
-
2.7.8.44 Staphylococcus aureus NCTC 8325 Q2G2X4
-
-
2.7.8.45 Staphylococcus aureus Q2G1C1
-
-
2.7.8.45 Staphylococcus aureus NCTC 8325 Q2G1C1
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.44 CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 Staphylococcus aureus CDP + 4-O-((2R)-1-glycerophospho)-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 ?
2.7.8.44 CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 Staphylococcus aureus NCTC 8325 CDP + 4-O-((2R)-1-glycerophospho)-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 ?
2.7.8.45 CDP-glycerol + 4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 Staphylococcus aureus CDP + 4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol enzyme TarF adds one unit of glycerol-3-phosphate to 4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol to produce (glycerol-3-phosphate)2-ManNAc-beta-(1,4)-GlcNAc-diphospho-lipid ?
2.7.8.45 CDP-glycerol + 4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 Staphylococcus aureus NCTC 8325 CDP + 4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol enzyme TarF adds one unit of glycerol-3-phosphate to 4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol to produce (glycerol-3-phosphate)2-ManNAc-beta-(1,4)-GlcNAc-diphospho-lipid ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.44 SA643
-
 Staphylococcus aureus
2.7.8.44 tarB
-
 Staphylococcus aureus
2.7.8.45 SAOUHSC_00223
-
 Staphylococcus aureus
2.7.8.45 tarF
-
 Staphylococcus aureus

General Information

EC Number General Information Comment Organism
2.7.8.45 physiological function gene products TarA, TarB, TarF, and TarL are required to convert the GlcNAc-diphosphate-lipid product of TarO to the full-length polyribitol polymer Staphylococcus aureus